医用金属硬组织植入物表面纳米涂层研究  

Research Progress of Nano Coatings on Biometals Implants

作　　者：韩建业[1,2] 余森[1] 于振涛[1] 牛金龙[1] 刘春潮[1] 刘汉源[1] 

机构地区：[1]西北有色金属研究院,陕西西安710016 [2]西安九洲生物材料有限公司,陕西西安710016

出　　处：《广东化工》2016年第15期146-147,共2页Guangdong Chemical Industry

基　　金：国家自然科学基金(31400821);国家国际科技合作项目(2014DFA30880);陕西省自然基金(2015JM3090)

摘　　要：细胞与人工植入物之间的相互作用是诱导形成骨整合界面的关键因素,然而这种相互作用大多取决于种植体表面的材料特性和表面形貌特征,纳米结构的表面已被证明能够增强细胞的黏附、增殖与分化。文章介绍了医用金属硬组织植入物表面纳米涂层的研究意义,综述了生物纳米涂层的主要制备方法及其物化性能特点,重点分析和讨论了生物纳米涂层对金属植入物的生物学性能影响和改善规律,最后介绍了生物纳米涂层研究与应用方面的最新进展。The functional success of a biomedical implant critically depends on its fast and stable bonding with the host tissue. Various biomedical metallic materials, including titanium alloys and biodegradable magnesium alloys, confer mechanical integrity to the device, but often these materials are not entirely suitable for direct integration with the host tissue, which leads to implant loosening and patient morbidity. The demand to develop surface modification technologies is rapidly increasing. Therefore, the nano coatings are an important selection. In the paper, the definition, classification and basic characteristics of nano coatings were introduced, and their development course was reviewed. Focuses on the improving of biocompatibility and biological functionality, the main preparation method of bio-nano-coatings were analyzed, together with the biological significance of interfacial bonding strength, the influence of the biological properties and improved methods. Finally, the latest developments about newly nano coatings are summarized.

关 键 词：金属植入物 纳米涂层 表面改性 生物活性 

分 类 号：TG146.3[一般工业技术—材料科学与工程] R318[金属学及工艺—金属材料]