针刺内关、太冲得气对原发性高血压患者胰岛素抵抗、血脂及血清TNF-α水平影响  

Effect of Insulin Resistance,Blood Lipid and TNF-αby Acupuncturing Deqi at Neiguan and Taichong on Patients with Primary Hypertension

作　　者：张贵锋[1,2] 闵水平 曾统军[3] 温鸿源[2] 林楚华[1,2] 王芳[1,2] 

机构地区：[1]肇庆医学高等专科学校,广东肇庆526020 [2]肇庆医学高等专科学校附属医院,广东肇庆526020 [3]南方医科大学附属顺德第一人民医院,广东佛山528000

出　　处：《辽宁中医药大学学报》2016年第8期106-109,共4页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：广东省中医药强省课题(20141306);肇庆市科技创新计划项目(2015040304-10)

摘　　要：目的:观察针刺内关、太冲得气对原发性高血压患者胰岛素抵抗、血脂及血清TNF-α水平的影响,探讨针刺得气与疗效的关系。方法:按照诊断纳入标准收治180例原发性高血压患者为研究对象,采用随机数字表法随机分为3组,每组60例。针刺得气组取受试者右侧内关穴、太冲穴施以真实的针刺,假针刺对照组在相同穴位施以假针刺,药物对照组口服苯磺酸左旋氨氯地平片,疗程均为14 d。比较治疗前后3组患者的胰岛素抵抗、血脂及血清TNF-α水平,并评价3种方法的临床治疗效果。结果:(1)针刺得气组、药物对照组、假针刺对照组总有效率分别为75.44%、85.00%、8.93%,针刺得气组与药物对照组差异无统计学意义,均显著高于假针刺对照组。(2)治疗前3组患者ISI、TNF-α比较无明显差异;治疗后针刺得气组、药物对照组ISI水平显著上升,TNF-α水平显著下降,但两组间比较无显著差异;假针刺对照组治疗前后相关指标无显著变化。(3)治疗前3组患者TG、TC、LDL、HDL水平无显著差异,治疗后针刺得气组、药物对照组TG、TC、LDL水平均显著下降,但两组间比较无显著差异,HDL水平均显著上升,且后者显著优于前者;假针刺对照组治疗前后相关指标无显著变化。结论:针刺内关、太冲得气可以改善原发性高血压患者胰岛素抵抗状态,降低血脂及血清TNF-α水平,效果与药物治疗相当,但假针刺相同穴位对上述指标无显著影响。Objective：To observe the effect of acupuncturing Deqi at Neiguan and Taichong Deqi on insulin resistance,blood lipid and serum TNF-α in patients with essential hypertension. To explore the relationship between acupuncture and therapeutic effect. Methods：180 patients with essential hypertension were included in the study according to the diagnostic criteria,and were randomly divided into 3 groups,60 cases in each group. Acupuncture group obtained by the test right Neiguan and Taichong to impose real acupuncture,sham acupuncture group at the same point subjected to sham acupuncture,drug control group was treated with benzene sulfonic acid levorotatory ammonia amlodipine,a course of 14 days. Before and after treatment,three groups of patients with insulin resistance,serum TNF-α and blood lipid levels were compared,and the antihypertensive effect of the three groups were compared. Results：（1）The total effective rate of acupuncture group,drug control group and sham acupuncture group were 75.44%,85%,8.93%,respectively. There was no significant difference between the acupuncture group and the drug control group,which were significantly higher than those of sham acupuncture group.（2）Before treatment,the ISI and TNF-α those in the patients of three groups were no significant difference. After treatment,acupuncture group and drug control group,the level of ISI increased significantly,TNF-α level was significantly decreased,but between the two groups no significant difference. There was no significant change in the control group before treatment and after treatment.（3）Before treatment,there was no significant difference in the levels of TG,TC,LDL and HDL between the three groups. After treatment,the levels of TG,TC and LDL were significantly decreased in the acupuncture group and the drug control group. But there was no significant difference between the two groups. After treatment,the level of HDL in the acupuncture group and the drug control group was significantly higher,and the drug control group i

关 键 词：针刺 得气 内关穴 太冲穴 原发性高血压 

分 类 号：R245.311[医药卫生—针灸推拿学] R259.441[医药卫生—中医临床基础]