药物预处理对介入治疗前后炎性反应及内皮功能变化的研究  

Effect of drug pretreatment on inflammatory reaction and endothelial function in unstable angina pectoris patients before and after PCI

作　　者：邵帅[1] 李广平[1] 石昭昭[2] 

机构地区：[1]天津医科大学第二医院心脏科天津心脏病学研究所,300211 [2]西安市第一医院心内科

出　　处：《中华老年心脑血管病杂志》2016年第8期826-828,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

摘　　要：目的观察曲美他嗪和普罗布考预处理对不稳定性心绞痛(UAP)患者PCI前后炎性反应指标的变化和影响。方法随机将175例UAP患者分为对照组61例、曲美他嗪组58例及普罗布考组56例,均在PCI术前即刻和术后次日检测血清高敏C反应蛋白(hs-CRP)、假性血管性血友病因子(vWF)以及NO水平。结果与同组术前比较,对照组术后hs-CRP及vWF水平升高(P<0.05),NO水平降低(P<0.05),曲美他嗪组和普罗布考组术后hs-CRP、NO及vWF水平较术前差异无统计学意义(P>0.05);曲美他嗪组及普罗布考组hs-CRP、NO及vWF差值水平分别较对照组降低[(0.08±2.52)mg/Lvs(0.21±2.72)mg/Lvs(0.88±1.80)mg/L,(-0.07±7.90)μmol/L vs(-1.16±8.58)μmol/L vs(-24.19±5.85)μmol/L,(0.19±0.13)μg/L vs(0.05±0.78)μg/L vs(0.43±0.72)μg/L,P<0.05)];曲美他嗪组差值与普罗布考组比较,差异无统计学意义(P>0.05)。结论PCI可引起UAP患者炎性反应,并且会造成血管内皮微小损伤,曲美他嗪或普罗布考预处理可减轻炎性反应及血管内皮功能的损伤。Objective To study the effect of trimetazidine and probucol pretreatment on hs-CRP,NO and vWF in UAP patients.Methods One hundred and seventy-five UAP patients were randomly divided into control group（n=61）,trimetazidine treatment group（n=58）and probucol treatment group（n=56）.Veinous blood sample was taken fore the measurement of their serum hs-CRP and NO level and vWF.Results The serum hs-CRP and vWF levels were significantly higher while the serum NO level was significantly lower in control group after PCI than before PCI（P〈0.05）.However,no significant differences was found in serum hs-CRP,NO and vWF levels between trimetazidine treatment group and probucol treatment group after PCI（P〉0.05）.The serum hs-CRP,No and vWF levels were significantly lower in trimetazidine treatment group（n=58）and probucol treatment group than in control group before and after PCI（0.08±2.52mg/L vs 0.21±2.72mg/Lvs 0.88±1.80mg/L,-0.07±7.90μmol/Lvs-1.16±8.58μmol/L vs-24.19±5.85μmol/L,0.19±0.13μg/L vs 0.05±0.78μg/L vs 0.43±0.72μg/L,P〈0.05）.However,no significant difference was found in thses parameters between trimetazidine treatment group and probucol treatment group（P〉0.05）.Conclusion PCI can induce inflammatory reaction and mild vascular endothelial function damage.Trimetazidine or probucol pretreatment can effectively reduce inflammatory reaction and vascular endothelial function damage.

关 键 词：曲美他嗪 普罗布可 C反应蛋白质 冠状动脉狭窄 内皮 血管 

分 类 号：R541.4[医药卫生—心血管疾病]