成纤维细胞生长因子21与糖尿病肾病相关性的临床研究  

Clinical Study of the relationship between serum FGF21 and diabetic nephropathy

作　　者：章建娜[1,2] 张骥[2] 孙梅[2] 陈朝生[2] 许菲菲[2] 史艳玲[2] 卢国元[1] 

机构地区：[1]苏州大学附属第一医院,江苏苏州215000 [2]温州医科大学附属第一医院,浙江温州325000

出　　处：《浙江医学教育》2016年第4期45-48,共4页Zhejiang Medical Education

基　　金：温州市科技计划项目(编号:2011S0280)

摘　　要：目的:探讨成纤维细胞生长因子21(FGF21)与糖尿病肾病的相关性。方法:随机选取不同分期2型糖尿病肾病患者各30例(共5期,150例))为实验组(A组),同期住院的2型糖尿病非肾病患者50例为B组,C组为健康体检志愿者50例,搜集所有研究对象的一般情况及临床、生化资料,测定血FGF21水平,并进行比较。结果:与B组及C组相比较,A组患者年龄、高血压、CVD家族史、血尿素氮、肌酐及尿酸明显升高(P<0.001),而高密度脂蛋白水平明显下降(P<0.001)。与B组患者相比较,A组患者24h尿蛋白定量明显升高、肌酐清除率明显下降(P<0.001)。3组患者血FGF21浓度存在明显差异(P<0.05),A组患者血FGF21浓度明显高于B、C组;A组患者,随着肾脏病分期的增加,血FGF21浓度逐渐升高(P<0.05);校正后Pearson相关分析显示A组患者血清FGF21水平与年龄、体重指数、空腹血糖、血肌酐、尿素氮及甘油三酯呈正相关(P<0.05),与高密度脂蛋白呈负相关(P<0.05)。结论:2型糖尿病肾病患者血清FGF21浓度明显升高,且随着肾病的进展,FGF21浓度有逐渐升高趋势,提示FGF21与糖尿病肾病存在一定相关性,可能参与疾病的发生与进展。[Objective] To discuss the relationship between Serum FGF21 and diabetic nephropathy （DN） .[Method] 150 pa-tients with DN were selected from CKD 1 to 5 stage as Group A and every stage includes 30 patients .50 cases patients with type II diabetes but not with DN as group B .Group C includes 50 volunteers of healthy physical examination .The expression of serum FGF 21 was determined by enzyme-linked immune sorbent assay （ELISA） .Then the clinicaland laboratory data were collected .The association between DN and FGF21was analyzed .[Result]（1） compared with group B and group C ,levels of serum BUN、Scr、UA and age、high blood pressure ,family history of CVD were obviously increase in group A （ P〈 0 .001 ） , but HDL-CH in group A is obviously decrease （ P〈0 .001 ） .Compared with group B ,creatinine clearance rate （Ccr ）in group A is obviously decrease and 24-hour urine protein quantitation is obviously increase （ P〈0 .001 ） .The blood concentrations of FGF21among three groups is significant difference （ P〈 0 .05 ） ,FGF21 concentrations of group A significantly higher than the other two groups .（2） With the progress of kidney disease from stage I to V ,the blood concentration of serum FG F 2 1 gradu-ally increased （ P〈 0 .05） .（3）Result of Pearson correlation analysis indicated that serum FGF21 level of group A was positive-ly correlated with age ,Body Mass Index ,FBG ,creatinine ,urea nitrogen and triglyceride （ P〈 0 .05 ） ,and was negatively correlated with HDL-CH （ P〈 0 .05 ） .[Conclusion] In patients with type 2 diabetic nephropathy FGF21 serum concentration＆amp;nbsp;increased significantly .With the progress of the kidney disease ,FGF21 concentration has increased trend .It indicated FGF21 have a certain correlation with diabetic nephropathy ,FGF21 may participate in the occurrence and the progress of diabetic nephropathy.

关 键 词：成纤维细胞生长因子21 糖尿病肾病 

分 类 号：R581.1[医药卫生—内分泌]