西尼地平和拉西地平对原发性高血压患者交感神经系统活性的影响  

The Clinical Observation of Cilnidipine to The Sympathetic Nervous System of Patients with Hypertension Compared with Lacidipine

作　　者：魏则文 

机构地区：[1]云南昆钢医院心内科,云南昆明650000

出　　处：《中国医药指南》2016年第22期21-22,共2页Guide of China Medicine

摘　　要：目的探讨分析西尼地平和拉西地平对原发性高血压患者交感神经系统活性的影响。方法 2011年1月至2014年6月我院共收集50例轻中度原发性高血压患者,根据治疗方法的不同将患者随机分入西尼地平组(n=25,10 mg/d)和拉西地平组(n=25,5 mg/d),治疗8周后,比较二组治疗前后握力试验结果,同时比较分析其静息血压和心率变化特点。结果用药8周后,西尼地平组和拉西地平组分别与其相应组别用药前收缩压和舒张压均显著降低(P<0.05);服药前两组握力试验血压和心率增加幅度基本一致,但在用药后握力试验西尼地平组心率增幅明显低于拉西地平组(P<0.05),差异具有统计学意义。结论原发性高血压患者服用西尼地平不仅可降低静息时血压,同时还可以避免患者负荷状态下交感神经系统的激活,值得临床应用推广。Objective To investigate Influence Cilnidipine and Lacidipine to sympathetic nervous system activity in patients with primary hypertension. Methods50 cases of mild to moderate hypertensive patients from January 2011 to June 2014 in our hospital were collected, depending on the treatment of the patients were randomly divided Cilnidipine group（n=25, 10 mg/d） and lacidipine group（n=25, 5 mg/d）, after treatment 8 weeks, two groups before and after treatment grip strength test results, and comparative analysis of their resting blood pressure and heart rate characteristics. Results After treatment of 8 weeks cilnidipine group and lacidipine group respectively before treatment systolic and diastolic blood pressure were significantly lower（P〈0.05）; grip strength test before taking two blood pressure and increased heart rate are basically the same magnitude, but after treatment grip strength test cilnidipine increase in heart rate was significantly lower than lacidipine group（P〈0.05）, a statistically significant difference. Conclusion Primary hypertension patients taking cilnidipine not only reduces resting blood pressure, while avoiding load condition is activated by the sympathetic nervous system of the patient, is worthy of clinical application and promotion.

关 键 词：高血压 西尼地平 拉西地平 

分 类 号：R544.1[医药卫生—心血管疾病]