干细胞技术对肝细胞癌的影响  

The Effect of Stem cell Technology on Hepatocellular Carcinoma

作　　者：李天然[1] 卢光明[2] 

机构地区：[1]解放军总医院第一附属医院放射科,北京100048 [2]南京军区南京总医院放射科,南京210000

出　　处：《医学综述》2016年第16期3125-3128,共4页Medical Recapitulate

基　　金：国家自然科学基金(81271607);南京军区医学科技创新经费资助项目(11Z035);福建省自然基金(2013J01392);中国博士后基金(2015M572810)

摘　　要：干细胞技术可分为正常干细胞技术和癌干细胞技术,骨髓间充质干细胞(BMSC)移植可促进肝组织再生,诱导肝癌细胞凋亡,但BMSC具有潜在的致瘤性。肝癌组织对BMSC具有趋化性,可定向分化肝细胞或肝癌细胞。肝癌细胞可来源于肝癌干细胞,肝前体细胞可分化为肝癌干细胞。肝癌细胞与干细胞相互影响、相互作用中发生的变化是肿瘤或干细胞演变的重要事件,对其深入研究将对基于干细胞技术的肿瘤生物治疗起到积极作用。Stem cell technology can be divided into the normal stem cells and cancer stem cells techno- logy. Bone marrow mesenchymal stem cells（ BMSC ） transplantation can promote liver tissue regeneration and induce tumor cells apoptosis. But BMSC has potential tumorigenicity. BMSC has a tendency of chemotaxis in HCC tissues and can be directedly differentiated into liver cells or liver cancer cells. Liver cancer cells can be derived from liver cancer stem cells. Hepatic progenitor cells can be differentiated into liver cancer stem cells. Changes are the important events in the evolution of the tumor or stem ceils in the interaction between liver cancer ceils and stem cells ,the in-depth study on which will play a positive role in biological therapy based on stem cell technology.

关 键 词：肝癌 干细胞 肝癌干细胞 肝前体细胞 

分 类 号：R34[医药卫生—基础医学]