2型糖尿病与认知障碍相关性磁共振研究现状及进展  

Research Status and Progress of Type 2 Diabetes and Cognitive Impairment Correlation by Magnetic Resonance Imaging

作　　者：王芳[1] 赵衡[1] 唐德秋[1] 刘进才[1] 

机构地区：[1]南华大学附属第一医院放射科

出　　处：《医学综述》2016年第16期3202-3206,共5页Medical Recapitulate

基　　金：湖南省高等学校科学研究重点项目(14A126);湖南省普通高等学校教学改革研究项目(2011-202);湖南省自然科学基金资助项目(14JJ2086);衡阳市科学技术发展计划项目(2013KJ52)

摘　　要：2型糖尿病(T2DM)与认知障碍相关,且使得罹患痴呆的风险增加。尽管研究表明T2DM是认知障碍的危险因素和阿尔茨海默病(AD)的潜在危险因素,但大家熟知的只有早期的受影响的神经生物学通路。随着过去几十年神经影像学的飞速发展,相关学者对T2DM如何影响脑部结构和功能改变以及可能导致AD有了深入了解。因此,基于结构磁共振成像、脑血流量、静息态功能磁共振成像来综述T2DM、认知障碍和AD的机制及其相互关联,重点是关于磁共振神经影像学如何为临床提供更为丰富的诊断信息,为T2DM干预方案的制订提供帮助。Type 2 diabetes mellitus （T2DM） has been associated with cognitive impairment and increased risk of dementia. Although marry studies have shown that T2DM is a risk factor for cognitive impair- merit and the potential risk factors for Alzheimer＇s disease （AD） ,the only well-known fact is the early affect- ed neurobiologlcal pathways. With the rapid development of the neuroimaging in past few decades, researchers have gained insight about how T2DM affects brain structure and function and possibly leads to AD. Here is to make a review of the pathogenesis of T2DM, cognitive impairment and AD, and the correlation between them from structure MRI, cerebral blood flow and resting state functional MRI, focusing on how the neureimaging provides more extensive clinical diagnostic information and help to make the clinical intervention programs.

关 键 词：2型糖尿病 认知障碍 阿尔茨海默病 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R589.1[医药卫生—诊断学]