天然产物防治急性肺损伤的作用机制研究进展  

Advances in the mechanism research of natural products against acute lung injury

作　　者：俞苏岚[1] 余秀[1] 寇俊萍[1] 

机构地区：[1]江苏省中药评价与转化重点实验室,中国药科大学中药复方研究室,南京211198

出　　处：《中国药科大学学报》2016年第4期397-403,共7页Journal of China Pharmaceutical University

基　　金：国家自然科学基金资助项目(No.81274131)~~

摘　　要：急性肺损伤(acute lung injury,ALI)是临床上常见的危重病症,发病率和致死率逐年增高,其本质为炎症反应失衡,引发弥漫性肺泡及肺血管内皮细胞损伤、肺组织水肿及肺不张等病理特征。其调控途径涉及NF-κB、MAPK等信号通路和TLRs、PPARγ、腺苷A2A等主要相关受体。天然产物在防治ALI方面日益受到关注,其作用机制研究也不断深入。本文综述近3年来天然产物对ALI病理特征的改善作用及其所涉及的信号通路和相关受体,以期为研制防治ALI的创新药物提供一定线索和依据。Acute lung injury（ALI） is a common critical disease with increasing morbidity and mortality rate in clinic. Its major pathological cause is the inflammation imbalance, which can cause diffuse alveolar and pulmonary vascular endothelial cell injury, lung edema and atelectasis. Many pathways and receptors, such as NF-κB and MAPK signaling pathways, and the adenosine A2A receptors, Toll-like receptors （TLRs）, peroxisome proliferator- activated receptor gamma （PPARγ）, etc. are involved in ALL Nowadays, prevention and treatment of ALI with natural products attract more and more attention. This article reviews the advances in the mechanisms research of natural products in recent three years against ALI so as to provide some references and clues for the development of innovative drugs to prevent and treat ALL

关 键 词：天然产物 急性肺损伤 病理特征 信号通路 受体 

分 类 号：R563[医药卫生—呼吸系统]