总胆红素水平、间接胆红素水平、胆红素与白蛋白摩尔比和急性胆红素脑病的相关性研究  

Correlation of acute bilirubin encephalopathy and total bilirubin, indirect bilirubin,bilirubin/albumin ratio

作　　者：赵枫[1] 

机构地区：[1]延安大学附属医院儿科,陕西延安716000

出　　处：《临床医学研究与实践》2016年第15期13-15,共3页Clinical Research and Practice

摘　　要：目的探讨总胆红素、间接胆红素以及胆红素与白蛋白摩尔比和急性胆红素脑病的相关性。方法比较分析收治的50例ABE患儿(轻度19例、中度16例、重度15例)和50例高胆红素但无ABE患儿病因、诱发ABE的危险因素以及T-BIL、IBIL、B/A对ABE的诊断价值。结果 ABE组患儿感染所占比例显著低于对照组,溶血中ABO溶血所占比例显著低于对照组,Rh溶血所占比例显著高于对照组,差异均具有显著性(P<0.05);T-BIL、IBIL、B/A对ABE有诊断价值,且当T-BIL=485μmol/L、IBIL=476μmol/L、B/A=0.948时对ABE诊断敏感性和特异性最高;4组患儿随ABE严重程度下降,T-BIL、IBIL、B/A水平呈明显下降趋势,差异具有统计学意义(P<0.05)。结论 ABE的发生与T-BIL、IBIL、B/A水平异常有关,三者对ABE的诊断和病情评估价值较高。Objective To explore the correlation for the patients with acute bilirubin encephalopathy and total bilirubin,indirect bilirubin, bilirubin/albumin ratio. Methods Fifty cases of children with ABE（19 cases were mild, 16 cases are medium, 15 cases were severe） and 50 cases with hyperbilirubinaemia but no ABE children were compared and analyzed,the etiological factor, risk factors, the values of T-BIL, IBIL, B/A for ABE were analyzed. Results The infection rate for the children in ABE group were lower than the control group（P〈0.05）; the rate of ABO hemolysis for the children in ABE group were lower than the control group（P〈0.05）; the rate of Rh hemolysis for the children in ABE group were higher than the control group（P〈0.05）; It has values of T-BIL, IBIL, B/A for ABE diagnosis, and when T-BIL=485 μmol/L, IBIL=476μmol/L, B/A=0.948, the sensitivity and specificity were the highest for ABE diagnosis; with ABE severity decreased, TBIL, IBIL, B/A were decreased significantly（P〈0.05）. Conclusion ABE are associated with the abnormal levels of T-BIL,IBIL and B/A. These three factors are valuable for the diagnosis and evaluation of the severity of ABE.

关 键 词：总胆红素 间接胆红素 胆红素与白蛋白摩尔比 急性胆红素脑病 

分 类 号：R722.1[医药卫生—儿科]