老年女性骨质疏松症患者静脉滴注唑来膦酸注射液急性期反应观察  

Observation on Acute-phase Reaction of Zoledronic Acid Injection in Elder Osteoporotic Women

作　　者：边平达[1] 寿张轩[2] 钱素凤[1] 应奇峰[1] 

机构地区：[1]浙江省人民医院望江山院区骨质疏松诊疗中心,杭州310024 [2]浙江省人民医院望江山院区药学部,杭州310024

出　　处：《药物流行病学杂志》2016年第7期432-434,共3页Chinese Journal of Pharmacoepidemiology

基　　金：浙江省医药卫生平台重点资助项目(编号:2016ZDAD02);浙江省人民医院优秀青年人员科研启动基金(编号:zry2015C002)

摘　　要：目的:观察老年女性骨质疏松症(OP)患者静滴唑来膦酸后急性期反应(APR)的发生情况。方法:47例老年女性OP患者静滴唑来膦酸注射液5 mg后,记录她们在72 h内发热、肌痛、流感样症状、头痛头晕、恶心呕吐等APR的发生情况。结果:35例(74.47%)患者出现1个或1个以上的APR,其中发热19例(40.43%),肌痛18例(38.30%),流感样症状14例(29.79%),头痛头晕13例(27.66%),恶心呕吐12例(25.53%)。发热患者伴随其他APR的平均个数(3.35±1.41)个明显高于不发热的患者的平均个数(1.40±0.63)个,差异有统计学意义(P<0.01)。且在发热患者中,最高体温与其他APR间具有相关性(r=0.577,P<0.05)。结论:老年女性OP患者静脉输注唑来膦酸后,易出现发热等APR,应重视静脉输注后的观察和处理。Objective： To investigate the incidence of acute-phase reaction（ APR） of zoledronic acid injection in elder osteoporotic women. Methods： APR（ ≤72h after 5 mg zoledronic acid injection infusion）,including fever,myalgia,influenza-like symptoms,headache,dizziness,nausea and vomiting,were recorded. Results： 35（ 74. 47%） cases had one or more APR,and the most common APR was fever（ 40. 43%）,followed by myalgia（ 38. 30%）,influenza-like symptoms（ 29. 79%）,headache and dizziness（ 27. 66%）,nausea and vomiting（ 25. 53%）. There was a significant difference in the average number of other APR observed between subjects presented with fever（ 3. 35 ± 1. 41） and those without（ 1. 40 ±0. 63）（ P〈0. 01）. Moreover,the higher body temperature were correlated to more incidences of other APR in feverish cases（ P〈0. 05）. Conclusion： There was a high incidence of APR in older osteoporotic women after treatment with zoledronic acid injection,as a result,close observation and proper treatment should be implemented to secure the safety of the patients.

关 键 词：唑来膦酸 骨质疏松症 急性期反应 发热 

分 类 号：R681[医药卫生—骨科学]