复方敏维糖浆的急性毒性和长期毒性研究  

Acute Toxicity and Long-term Toxicity of Compound Minwei Syrup

作　　者：王建茹[1] 王国辉[2] 张立新[2] 张伟[2] 

机构地区：[1]唐山市妇幼保健院检验科,河北唐山064000 [2]唐山市妇幼保健院药剂科,河北唐山064000

出　　处：《中国药师》2016年第8期1578-1580,共3页China Pharmacist

摘　　要：目的:为复方敏维糖浆的临床安全使用提供实验依据。方法:急性毒性实验以小鼠为实验对象,以改良寇氏法计算半数致死量(LD_(50))。长期毒性实验中给予大鼠高、中、低剂量(650,195,65 mg·kg^(-1))的复方敏维糖浆,连续给药4周,停药2周后观察其一般状况、体质量、摄食量,测定血液学、血液生化学指标,解剖后裸眼观察主要靶器官(心、肺、肾、肝)变化。结果:急性毒性实验中复方敏维糖浆小鼠的LD_(50)为5 581.8 mg·kg^(-1)。长期毒性实验中高剂量组大鼠血清谷草转氨酶(AST)、谷丙转氨酶(ALT)、总胆固醇(CHOL)均有一定程度升高,且大鼠自发活动减少、有困倦现象,摄食量和体质量均有一定下降。结论:复方敏维糖浆小鼠的LD_(50)为5 581.8 mg·kg-1,急性毒性反应与神经系统有关,未见脏器有明显损伤。长期使用高剂量复方敏维糖浆(650 mg·kg-1)可引起大鼠AST、ALT、CHOL升高。Objective： To provide experimental evidence for the clinical safe use of compound Minwei syrup. Methods： In the acute toxicity test,the LD_（50） of compound Minwei syrup was determined according to the modified Kou Shi method. In the long-term test,the SD rats were given compound Minwei syrup at high,medium and low dose（ 650,195 and 65 mg·kg^（- 1））,three times a day for consecutive 4 weeks. The changes of general condition,food intake and body weight were recorded,and hematological index,blood biochemical index and histomorphology of organs and tissues were observed after 2-week withdrawal. Results： The LD_（50） of compound Minwei syrup for mice was 5 581. 8 mg·kg^（- 1）. Compound Minwei syrup could increase plasma AST,ALT and CHOL in rats,decrease locomotion activity,food intake and weight of rats with long-term use. Conclusion： The LD_（50） of compound Minwei syrup for mice is5 581. 8 mg·kg^（- 1）,and its acute toxicity is mainly in nervous system without organ injuries. Compound Minwei syrup（ 650 mg·kg^（- 1）） can increase plasma AST,ALT and CHOL in long-term use.

关 键 词：复方敏维糖浆 急性毒性 长期毒性 

分 类 号：R965.3[医药卫生—药理学]