二至丸对D-半乳糖诱导衰老模型大鼠脑组织线粒体呼吸链复合物Ⅰ、Ⅳ含量的影响  

Erzhi pill on mice' mitochondrial respiratory chain complexes Ⅰ,Ⅳ content induced by D-galactose

作　　者：赵雪莹[1] 韩伟丽[1] 徐丹[1] 高长玉[1] 

机构地区：[1]黑龙江中医药大学,哈尔滨150040

出　　处：《长春中医药大学学报》2016年第4期676-678,共3页Journal of Changchun University of Chinese Medicine

基　　金：黑龙江中医药大学博士创新基金(B201102);黑龙江中医药大学优秀青年教师支持计划项目;黑龙江省博士后科研启动金资助项目(LBH-Q12009);黑龙江省教育厅青年学术骨干项目(1253G053)

摘　　要：目的观察二至丸对D-半乳糖致衰老模型大鼠脑组织线粒体呼吸链复合物Ⅰ、Ⅳ含量的影响,探讨二至丸抗氧化的作用机制。方法采用D-半乳糖诱导衰老模型大鼠,测定大鼠脑组织线粒体呼吸链复合物Ⅰ、Ⅳ含量。结果二至丸各治疗组较模型对照组大鼠脑组织线粒体呼吸链复合物Ⅰ、Ⅳ含量显著降低。结论二至丸能够提高机体的抗氧化能力,可能与其能够降低体内活性氧含量有关,从而延缓机体的衰老进程。Objective To study the effect of Erzhi pill on mice＇mitochondrial respiratory chain complexes Ⅰ,Ⅳ content induced by D-galactose,and discuss the mechanism of antioxidant effect of Erzhi pill.Methods Determinate mitochondrial respiratory chain complexes Ⅰ,Ⅳ content with aging mice models induced by D-galactose.Results All doses of Erzhi pill groups could significantly reduce the mitochondrial respiratory chain complexes Ⅰ,Ⅳ content which compared with model group.Conclusion Erzhi pill could improve the body＇s antioxidant capacity,and delay body＇s aging process.

关 键 词：二至丸 D-半乳糖 线粒体呼吸链复合物 Ⅰ、Ⅳ 衰老 

分 类 号：R285.5[医药卫生—中药学]