安理申联合银杏叶治疗血管性认知障碍  

Aricept combined with Ginkgo Biloba Leaves extract tablets in treatment of vascular cognitive impairment

作　　者：贺大权[1] 秦雪颖 赵丹华[1] 才丽娜[1] 白晋[1] 温宏峰[1] 

机构地区：[1]航天中心医院神经内科,北京100049

出　　处：《长春中医药大学学报》2016年第4期765-767,共3页Journal of Changchun University of Chinese Medicine

摘　　要：目的观察和分析安理申联合银杏叶治疗血管性认知障碍(VCI)的疗效。方法选取150例VCI患者作为研究对象,将其随机分为A、B、C 3组,各50例,A组给予单独口服银杏叶片治疗,B组给予单独口服安理申治疗,C组给予口服安理申联合银杏叶片治疗。对3组治疗前、后简明智力状态检查量表(MMSE)、蒙特利尔认知评估量表(Mo CA)、韦克斯勒记忆量表(WMS)、日常生活能力量表(ADL)评分及临床疗效进行观察和比较。结果 C组治疗后MMSE评分、Mo CA评分、WMS评分显著高于B组,且ADL评分显著低于B组,B组MMSE评分、Mo CA评分、WMS评分显著高于A组,且ADL评分显著低于A组,差异均有统计学意义(P<0.05);C组疗效分布和临床有效率均优于B组,B组疗效分布和临床有效率均优于A组,差异均有统计学意义(P<0.05)。结论在VCI的治疗中应用安理申联合银杏叶片,能显著改善患者的认知功能和日常生活能力,显著改善临床症状。Objective To observe and analyze the therapeutic effects of Aricept combined with Ginkgo Biloba Leaves Extract Tablets in the treatment of vascular cognitive impairment （VCI）.Methods The 150 cases of patients with VCI were selected as the research objects and randomly divided into group A,group B and group C,50 cases were included into each group.The patients in group A were treated with single oral treatment of Ginkgo Biloba Leaves Extract Tablets.The patients in group B were treated with single oral Aricept treatment.The patients in group C were treated with oral Aricept combined with Ginkgo Biloba Leaves Extract Tablets treatment.The mini mental state examination （MMSE） score,the Montreal cognitive assessment （MoCA） score,the Wechsler Memory Scale （WMS） score,the ability of daily life scale （ADL） score of the patients in the three groups before and after the treatment and the therapeutic effects were observed and compared.Results MMSE score,MoCA score,WMS score after the treatment of the patients in group C were significantly higher than those in group B and ADL score was significantly lower than that in group B.MMSE score,MoCA score,WMS score after the treatment of the patients in group B were significantly higher than those in group A and ADL score was significantly lower than that in group A.The differences were statistically significant （P ＜0.05）;The distribution of the therapeutic effects and the clinical efficiency of the patients in group C were better than those in group B.The distribution of the therapeutic effects and the clinical efficiency of the patients in group B were better than those in group A.The differences were statistically significant （P ＜ 0.05）.Conclusion In the treatment of VCI,the application of Aricept combined with Ginkgo Biloba Leaves treatment can significantly improve the patient＇s cognitive function and activities of daily living,has more significant clinical therapeutic effects.

关 键 词：安理申 银杏叶片 血管性认知障碍 

分 类 号：R255.2[医药卫生—中医内科学]