炎性因子与动脉硬化闭塞症中医证型相关性研究  

Research on the Correlation between Inflammatory Factors and the Syndromes of Traditional Chinese Medicine in Arteriosclerosis Obliterans

作　　者：宋奎全[1] 张恒龙[1] 陈柏楠[2] 

机构地区：[1]济南市中医医院普外科,济南250012 [2]山东省中医院周围血管病科,济南250014

出　　处：《中国中西医结合外科杂志》2016年第4期315-317,共3页Chinese Journal of Surgery of Integrated Traditional and Western Medicine

基　　金：国家中医药管理局年度国家中医临床研究基地业务建设科研专项课题(JDZX2012110)

摘　　要：目的:研究炎性因子与动脉硬化闭塞症中医证型的相关性。方法:筛选动脉硬化闭塞症患者90例,其中血脉瘀阻组45例,湿热毒盛组45例,测定血清中白介素1(IL-1)、超敏C反应蛋白(Hs-CRP)、肿瘤坏死因子α(TNF-α)的水平,分析不同炎性因子与动脉硬化闭塞证中医证型的相关性。结果:血脉瘀阻组IL-1为0.246±0.442,湿热毒盛组为0.258±0.568,二组间无差别(P>0.05)。血脉瘀阻组Hs-CRP为3.718±3.888,湿热毒盛组为12.105±9.807,两组间差别明显(P<0.01)。血脉瘀阻组TNF-α为1.664±0.147,湿热毒盛组为1.704±0.284,两组间无差异(P>0.05)。结论:Hs-CRP与动脉硬化闭塞症中医证型关系密切,可作为判定动脉硬化闭塞症中医证型的参考指标。Objective To research the correlation between inflammatory factors and the syndromes of Traditional Chinese Medicine in arteriosclerosis obliterans. Methods Screening of 90 patients with arteriosclerosis obliterans, 45 cases were those of blood stasis syndrome,and 45 cases were that of damp heat syndrome. The levels of serum interleukin 1 （IL-1）, high sensitive C reactive protein （Hs-CRP） and tumor necrosis factor α（TNF-α） were determined, and the correlation between different inflammatory factors and the syndromes of Traditional Chinese Medicine was analyzed in arteriosclerosis obliterans. Results There were no significant difference in serum concentrations of IL-1 and TNF-α between blood stasis syndrome group and damp heat syndrome group （0.246±0.442 vs 0.258±0.568 and 1.664±0.147 vs 1.704±0.284, P〉0.05）. But for Hs-CRP, there was significant difference between blood stasis syndrome group and damp heat syndrome group （3.718 ± 3.888 vs 12.105±9.807, P〈0.01）. Conclusion It is closely related between Hs-CRP and the syndromes of Traditional Chinese Medicine in Arteriosclerosis obliterans, Hs-CRP can be used as a reference index of the syndromes of Traditional Chinese Medicine in arteriosclerosis obliterans.

关 键 词：动脉硬化闭塞症 炎性因子 中医证型 

分 类 号：R654.4[医药卫生—外科学]