无偿献血者传染性标志物合并阳性感染情况分析  

Analysis on merged positive infection situation of contagious serum markers in voluntary blood donors

作　　者：冯娟[1] 冀慧[1] 

机构地区：[1]安阳市中心血站,河南455000

出　　处：《现代医药卫生》2016年第16期2493-2495,共3页Journal of Modern Medicine & Health

摘　　要：目的探讨无偿献血人群丙氨酸氨基转移酶（ALT）、乙型肝炎表面抗原（HBs Ag）、丙型肝炎病毒抗体（抗-HCV）、人类免疫缺陷病毒抗体（抗-HIV）与梅毒螺旋体抗体（抗-TP）等指标合并阳性感染情况及人群分布特点,为制订血液筛查标准提供依据。方法对2010~2014年安阳市无偿献血者293 310例血液标本中,127例合并阳性感染2项及以上传染性标志物的血液标本进行统计分析。结果 ALT＋HBs Ag阳性标本51例,ALT＋抗-HCV阳性标本37例,ALT＋抗-TP阳性标本14例,HBs Ag＋抗-HCV阳性标本3例,HBs Ag＋抗-TP阳性标本5例,抗-HCV＋抗-TP阳性标本6例,抗-HCV＋抗-HIV阳性标本3例,抗-TP＋抗-HIV阳性标本6例,ALT＋HBs Ag＋抗-HCV阳性标本1例,ALT＋抗-HCV＋抗-HIV阳性标本1例。传染性标志物合并阳性感染人群分布特征：不同性别、不同年龄组及不同居住地传染性标志物合并阳性发生率比较,差异均有统计学意义（χ~2=10.80、12.18、8.43,P〈0.05）。ALT不合格率与HBs Ag、抗-HCV导致的ALT不合格率比较,差异均无统计学意义（P〉0.05）。结论 ALT检测不能作为是否感染乙型肝炎病毒或HCV的特异性检测指标。TP合并其他感染较多,应加强献血人群梅毒筛查和预防的宣传教育工作,更有利于输血安全。Objective To explore the merged positive infection situation of ALT,HBs Ag,anti-HCV antibody,anti-HIV antibody and anti-TP antibody in voluntary blood donors and their population distribution characteristics so as to provide a basis for formulating the blood screening standard. Methods Among 293 310 blood specimens in voluntary blood donors during2010-2014,127 cases of merged positive infection of 2 contagious serum markers or more were statistically analyzed. Results Fifty-one specimens were ALT ＋HBs Ag positive,37 specimens were ALT ＋anti-HCV positive,14 specimen were ALT ＋anti-TP positive,3 specimens were HBs Ag＋anti-HCV positive,5 specimen were HBs Ag ＋anti-TP positive,6 specimen were anti-HCV ＋an ti-TP positive,3 specimen were anti-HCV ＋anti-HIV positive,6 specimens were anti-TP ＋anti-HIV positive,1 specimen was ALT＋ HBs Ag＋anti-HCV positive and 1 specimen was ALT＋ anti-HCV＋anti-HIV positive. The distribution characteristics of the population with contagious serum markers merged positive infection were as follows ：the merged positive occurrence rates of contagious serum markers had statistical differences between genders and among different age groups and different residence places（χ2=10.80,12.18,8.43,P〈0.05）. Comparing the ALT disqualification rate with the ALT disqualification rate of HBs Ag and anti-HCV, the difference was not statistically significant（P〉0.05）. Conclusion The ALT detection can not serve as a specific detection index of HBV or HCV infection. TP merged other infections are common. The prevention and propaganda education work of syphilis screening should be strengthened, which is more conducive to blood transfusion safety.

关 键 词：生物学标记 供血者 传染病控制 HIV 肝炎表面抗原 乙型 河南 

分 类 号：R512.91[医药卫生—内科学]