增强型体外反搏治疗心绞痛的作用机制及其对炎症因子的影响  

Mechanism of EECP in treatment of angina pectoris and its influence on inflammatory factors

作　　者：刘盼 郑文武 蒋灿 黄冬梅 刘茜 李丹 廖双华 

机构地区：[1]西南医科大学附属医院心内科,四川泸州646000

出　　处：《现代医药卫生》2016年第16期2496-2497,2500,共3页Journal of Modern Medicine & Health

摘　　要：目的探讨增强型体外反搏(EECP)治疗心绞痛的作用机制。方法选取该院2014年1月至2015年9月收治的慢性缺血性心绞痛患者56例,随机分为治疗组(39例)和对照组(17例)。两组患者均进行常规治疗和检查,治疗组患者由医护人员全程陪同进行EECP治疗。采用酶联免疫吸附试验法测定两组患者的金属基质蛋白酶-9(MMP-9)及肿瘤坏死因子-α(TNF-α)的水平,对比分析两组患者的疗效。结果治疗后,治疗组的有效率[92.3%(36/39)]高于对照组[41.2%(7/17)],差异有统计学意义(P<0.01);两组患者的MMP-9及TNF-α水平均优于治疗前,且治疗组优于对照组,差异均有统计学意义(P<0.05)。结论 EECP治疗能降低MMP-9及TNF-α水平,改善心绞痛症状。Objective To investigate the action mechanism of the enhanced external counter pulsation（EECP） for treating angina pectoris. Methods Fifty-six patients with chronic ischemic angina pectoris in our hospital from January 2014 to September 2015 were selected and randomly divided into the treatment group（39 cases） and the control group（17 cases）. The two groups were performed the routine therapy and examinations. The patients in the treatment group were performed EECP accompa-nied by the medical staff in the whole process. ELISA was adopted to detect MMP-9 and TNF-α levels. The curative effects of the two groups were comparatively analyzed. Results The effective rate after therapy in the treatment group was 92.3%（36/39）,which was higher than 41.2%（7/17） in the control group,the difference was statistically significant（P〈0.01）;the MMP-9 and TNF-α levels after treatment in the two groups were superior to those before treatment,moreover the treatment group was superior to the control group,the difference was statistically significant（P〈0.05）. Conclusion The EECP therapy can decrease the levels of TNF-α and MMP-9 and improve the symptoms of angina pectoris.

关 键 词：反搏动术 心绞痛 基质金属蛋白酶类 肿瘤坏死因子Α 炎症 

分 类 号：R605.974[医药卫生—急诊医学]