益血生胶囊联合蔗糖铁注射液对妊娠贫血患者血清转铁蛋白受体及妊娠结局的影响  

Effect of Yi Xuesheng Jiaonang combined with Iron Sucrose Injection on serum transferrin receptor and pregnancy outcome with anemia patients in pregnancy

作　　者：章红英 陈淑群[2] 

机构地区：[1]慈溪市第三人民医院妇产科,浙江慈溪315324 [2]慈溪市妇幼保健院妇女保健,浙江慈溪315300

出　　处：《中国生化药物杂志》2016年第6期158-160,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的探究益血生胶囊联合蔗糖铁注射液对妊娠贫血患者血清转铁蛋白受体及妊娠结局的影响。方法收集2014年12月～2015年12月慈溪市第三人民医院妇产科收治的妊娠贫血患者78例,根据治疗方法不同分为对照组和试验组,每组各39例。2组均实施常规治疗以及对症治疗,对照组给予蔗糖铁注射液200 mg＋0.9%氯化钠注射液100mL静脉滴注,每周2次;试验组在对照组的基础上给予益血生胶囊4粒口服,每天3次。2组患者一个周期均为28 d,共治疗1个周期。治疗结束后对比分析2组患者临床疗效、血清转铁蛋白受体、肝肾功能以及不良妊娠结局发生率。结果治疗后2组血清转铁蛋白受体水平升高（P〈0.05）,与对照组相比,试验组血清转铁蛋白受体水平较高（P〈0.05）,与对照组相比,试验组丙氨酸氨基转移酶（alanine aminotransferase,ALT）、天门冬氨酸氨基转移酶（aspartate aminotransferase,AST）、血肌酐（serum creatinine,Cr）及尿素氮（urea nitrogen,BUN）等肝肾功能指标比较差异无统计学意义。2组不良妊娠结局发生率比较差异无统计学意义。结论益血生胶囊联合蔗糖铁注射液对妊娠贫血患者临床疗效显著,血清转铁蛋白受体水平上调,药物安全性较高,不良妊娠结局发生率较低。Objective To explore the effect of Yi Xuesheng Jiaonang combined with Iron Sucrose Injection on anemia in pregnancy on serum transferrin receptor and pregnancy outcome. Methods 78 patients with anemia in pregnancy form December 2014 to December 2015 of the third people＇s Hospital of Cixi were collected and randomly divided into control group and treatment group,each had 39 cases. Control group was given 200 mg Iron Sucrose Injection with 100mL 0. 9% sodium chloride injection intravenous infusion,2 times a week; experiment group were treated on the base of control group with 4 pills of Yi Xuesheng Jiaonang,3 times daily. The course was 28 d,and two groups all with a course treatment. After the end of treatment,clinical curative effect,serum transferrin receptor level,liver and renal function and the incidence of adverse pregnancy outcome were observed and compared.Results Serum transferrin receptor levels were increased in two groups after treatment（ P〈0. 05）,compared with control group,serum transferrin receptor level of treatment group was even higher（ P〈0. 05）,alanine aminotransferase（ ALT）,aspartate aminotransferase（ AST）,serum creatinine（ Cr） and urea nitrogen（ BUN） and other indicators of liver and kidney function of experiment group had no statistical significance. Adverse pregnancy outcome rate betwen two groups was not statistically significant. Conclusion Yi Xuesheng Jiaonang combined with Sucrose Iron Injection therapy for patients with anemia of pregnancy can significantly increased serum transferrin receptor levels,has higher safety and low adverse pregnancy outcomes rate.

关 键 词：益血生胶囊 蔗糖铁注射液 妊娠贫血 转铁蛋白受体 妊娠结局 

分 类 号：R556.9[医药卫生—血液循环系统疾病]