银杏叶提取物注射液联合甲钴胺治疗糖尿病周围神经病变的Meta分析  

Efficacy of ginkgo biloba extract injection combined mecobalamine in treatment of diabetic peripheral neuropathy: a Meta-analysis

作　　者：翁绕波 谷雪梅[2] 

机构地区：[1]温州医科大学附属舟山医院内分泌科,浙江舟山316000 [2]温州医科大学附属第一医院内分泌科,浙江温州325000

出　　处：《中国生化药物杂志》2016年第6期207-212,共6页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的系统评价试验组（银杏叶提取物注射液联合甲钴胺）与对照组（单用甲钴胺）对治疗糖尿病周围神经病变患者的临床疗效。方法检索中国知网全文数据库（CNKI）、维普数据库（VIP）、万方数据库、Pub Med,Cochrane图书馆及Google学术搜索等（检索文献截止时间为2015年12月31日）,收集有关银杏叶提取物注射液联合甲钴胺治疗对糖尿病周围神经病变患者疗效的随机对照研究。应用Rev.Man 5软件进行META分析,绘制森林图和漏斗图。结果共获得符合标准的研究21个,共1745例糖尿病周围神经病变患者,其中试验组905例,对照组840例。Meta分析结果显示,试验组总有效率优于对照组（RR=1.40,95%CI：1.31～1.48）,运动神经正中神经（MD=5.39,95%CI：3.90～6.87）和腓总神经（MD=5.33,95%CI：3.82～6.83）、感觉神经正中神经（MD=4.31,95%CI：2.89～5.74）和腓总神经（MD=4.10,95%CI：2.67～5.54）传导速度均优于对照组,差异均有统计学意义（P〈0.05）。结论银杏叶提取物注射液联合甲钴胺治疗糖尿病周围神经病变患者的RCT设计存在缺陷,影响研究结果的真实性和可靠性;银杏叶提取物注射液联合甲钴胺可提高临床疗效,改善神经传导速度;由于纳入的研究数量较少,研究质量不统一,仍需开展更多高质量的临床随机对照试验来进一步验证该项结果。Objective To evaluate the efficacy of ginkgo biloba extract injection combined mecobalamine treatment of diabetic peripheral neuropathy. Methods CNKI,CBM,VIP,Wanfang,Pub Med,Cochrane library and Google academic search and other databases were searched,the RCT related ginkgo biloba extract injection combined mecobalamine treatment of diabetic peripheral neuropathy were collected. Meta analysis,drawing forest map and funnel plot by using Rev. Man 5 software. Results A total of 21 RCTs involving 1745 patients were obtained,905 cases in experimental group and 840 cases in control group. Meta analysis showed that the total effective rate of the experimental group was better than that of control group（ RR= 1. 40,95% CI： 1. 31-1. 48）,the conduction velocity of motor nerve median nerve（ MD = 5. 39,95% CI： 3. 90-6. 87）,common nerve（ MD = 5. 33,95% CI： 3. 82-6. 83）,sensory nerve median nerve（ MD = 4. 31,95% CI： 2. 89-5. 74） and common nerve（ MD = 4. 10,95% CI： 2. 67-5. 54） in experimental group were better than those of control group,the difference was statistically significant（ P〈0. 05）. Conclusion Ginkgo biloba extract injection plus cobalt-amine peripheral neuropathy in patients with diabetes treatment RCT design flaws,affecting the results of the authenticity and reliability; ginkgo biloba extract injection combined mecobalamine can improve the clinical efficacy and improve nerve conduction speed; due to less number of included studies,research quality is not uniform,still need to carry out more high quality randomized controlled trials to further validate the results.

关 键 词：银杏叶提取物 甲钴胺 随机对照试验 META分析 

分 类 号：R587.2[医药卫生—内分泌]