HOXA10基因与不孕症关系的研究进展  

Research progress of the relationship between HOXA10 gene and infertility

作　　者：白云[1] 武泽[1] 

机构地区：[1]云南省第一人民医院,昆明理工大学附属医院,生殖医学科,昆明650032

出　　处：《生殖与避孕》2016年第8期672-677,共6页Reproduction and Contraception

基　　金：云南省卫生科技计划项目资助,项目编号:2016NS212

摘　　要：子宫内膜容受性(ER)的建立是妊娠的关键性前提。ER的降低是不孕症的主要因素之一。HOXA10基因近年来被认为在ER的建立过程中具有重要意义,子宫内膜HOXA10表达增加是内膜具有良好容受性的必要条件,与胚胎着床密切相关,目前已将HOXA10作为ER建立的标志物之一。本文旨在对于子宫内膜异位症(EMS)、多囊卵巢综合征(PCOS)、输卵管积水及控制性超促排卵(COH)治疗不孕症患者的HOXA10基因是否存在异常表达的相关研究进展进行综述,希望能为治疗相关不孕症提供新的思路。The establishment of endometrial receptivity （ER） is a crucial prerequisite for pregnancy. Insufficient of ER is one of the main factors of infertility. In recent years, HOXAIO gene was found to have an important significance in the process of establishing ER, and the increase in endometrial HOXAIO expression is necessary for well ER, which is closely related to embryo implantation. Nowadays, HOXA 10 has been treated as one marker of ER. This article is intended to review the relevant research progress about the expression of HOXAIO gene in the endometriosis （EMS）, polycystic ovary syndrome （PCOS）, hydrosalpinx, and the infertile patients treated by controlled ovarian hyperstimulation （COH）, which is hoped to provide a new idea for the treatment of related infertility.

关 键 词：HOXA10基因 不孕症 子宫内膜容受性(ER) 

分 类 号：R711.6[医药卫生—妇产科学]