疏风解毒胶囊解热作用机制研究  

Study on mechanism for antipyretic effects of Shufeng Jiedu Capsule

作　　者：刘静[1] 马莉[1] 陆洁[1] 田兴美[1] 许浚[1] 申秀萍[1] 张宗鹏[1] 张铁军[1] 

机构地区：[1]天津药物研究院,天津300193

出　　处：《中草药》2016年第12期2040-2043,共4页Chinese Traditional and Herbal Drugs

摘　　要：目的探讨疏风解毒胶囊解热作用机制。方法采用酵母致大鼠发热模型,观察疏风解毒胶囊给药后对体温调节相关因子:白细胞介素-1α(IL-1α)、IL-1β、IL-6、肿瘤坏死因子α(TNF-α)、γ干扰素(IFN-γ)、前列腺素E_2(PGE_2)、环腺苷酸(cAMP)、鸟腺苷酸(cGMP)、Na^+,K^+-ATPase、精氨酸升压素(AVP)的影响。结果疏风解毒胶囊能显著降低模型大鼠血清和下丘脑中炎症因子PGE_2和细胞因子TNF-α、IL-6、IL-1α、IL-1β水平,显著降低模型大鼠血清和下丘脑中致热介质cAMP水平及cAMP/cGMP值,显著降低下丘脑中Na^+,K^+-ATPase,减少产热,显著升高下丘脑中内源性解热介质AVP的量。结论疏风解毒胶囊有显著的解热作用,其通过减少炎症因子PGE_2及细胞因子水平、减少致热介质、减少产热、增加AVP的量,从而发挥解热作用。Objective To study the antipyretic effect of Shufeng Jiedu Capsules （SJC） and its mechanism. Methods Using the yeast-reduced fever model of rats to study the antipyretic effects of SJC and its mechanism, collecting blood plasma and hypothalamus to measure the indicators related to body temperature such as IL-1α, IL-1β, TNF-α, IFN-y, PGE2, cAMP, cGMP, Na-K-ATPase, IL-6, and AVE Results SJC can significantly decline the contents of TNF-α IL-6, IL-1 ct, and IL-1β, and it can also decline the content of pyrogenic medium-cAMP, ratio of cAMP/cGMP, reduce thermogenesis and levels of Na＋, K＋-ATPase, and significantly enhance the content of endogenous antipyretie medium-AVE Conclusion SJC has a significant antipyretic effect which could decline pyrogenic medium and reduce thermogenesis through reducing the content of inflammatory cytokines-PGE2 and cytokines, it also enhances the content of endogenous antipyretic mediurn-AVP to play its antipyretic effect.

关 键 词：疏风解毒胶囊 解热作用 白细胞介素 肿瘤坏死因子 Γ干扰素 前列腺素E_2 环腺苷酸 鸟腺苷酸 Na^+ K^+-ATPase 精氨酸升压素 

分 类 号：R285.5[医药卫生—中药学]