色氨酸2，3-双加氧酶在色氨酸分解代谢及免疫调节中的作用  

Effects of the tryptophan 2,3- dioxygenase in tryptophan metabolism and immunoregulation

作　　者：李善宝[1] 徐军明[1] 

机构地区：[1]上海交通大学附属第一人民医院普外科,上海200080

出　　处：《国际外科学杂志》2016年第7期491-494,共4页International Journal of Surgery

基　　金：基金项目：上海市科委科研计划项目（15411962700）

摘　　要：色氨酸2，3-双加氧酶（TDO）是催化色氨酸由犬尿氨酸（Kyn）途径分解代谢的限速酶。TDO主要在肝内降解色氨酸，调整体内色氨酸水平，能够抑制T细胞增殖，参与抗菌及炎性反应。代谢产物Kyn为芳烃受体（AhR）的内源性配体，TDO-Kyn-AhR通路具有调节肿瘤生长作用。随着对TDO介导色氨酸代谢免疫机制研究的不断积累，其在肿瘤治疗及移植免受耐受领域的应用前景令人期待。本文就TDO介导的色氨酸分解代谢及免疫调节作用进行综述。Tryptophan 2,3-dioxygenase （TDO）is the rate-limiting enzyme in the catabolism of Trp along the kynurenine pathway. Trip is mainly catabilized by the TDO in the liver, which could not only regulate the concentra- tion of the Trp and suppress the T cells proliferation, but also participate in antibacterial action and inflammatory re- sponse. The metabolin kynurenines as an endogenous ligand of the AhR receptor, the TDO enzymes, Kyn and AhR form the TDO- Kyn- AhR pathway have effects of regulatory the growth of tumor. With the research of the mechanism of immune regulation goes luther, it is expected to be a promising prospect in cancer therapy and the immune toler- ance of transplantation. We reviewed in the article, which summarized the TDO mediated catabolism of Trip and im- munomodulatory effect.

关 键 词：色氨酸2  3-双加氧酶 色氨酸 肿瘤治疗 免疫耐受 肝移植 

分 类 号：R285.5[医药卫生—中药学]