核受体在胆结石形成中的作用机制  

Mechanisms of nuclear receptors in gallstone formation

作　　者：朱琪[1] 阎波[1] 

机构地区：[1]上海市浦东新区人民医院普外科,上海201200

出　　处：《国际外科学杂志》2016年第7期499-502,共4页International Journal of Surgery

摘　　要：胆石症是临床常见病，特别是在女性和某些特殊种族群体。非水溶性胆固醇晶体的形成是由于胆汁中的胆固醇、胆盐、磷脂二三个主要脂质之间的失衡造成的。而许多参与肝脏内胆汁脂质分泌的蛋白质是受几个转录因子所调控的，包括核受体肝脏X受体和胆汁酸受体。有证据证实，在人类以及小鼠的基因和病理生理中，胆结石的形成和这些核受体具有相关性。此外，最新的资料还表明，雌激素受体在异常胆固醇代谢中的作用会导致胆结石疾病的发生。因此，更好的研究核受体在胆结石形成中的作用机制，将有助于医师在临床工作中制订对胆结石疾病更有效的治疗策略。Gallstone disease is highly prevalent in clinic, particularly in women and some specific ethnic groups. The formation of water-insoluble cholesterol crystals is due to a misbalance between the three major lipids present in the bile： cholesterol, bile salts, and phospholipids. Many proteins implicated in biliary lipid secretion in the liver are regulated by several transcription factors, including nuclear receptors LXR and FXR. Human and mu- rine genetic, pathophysiological evidence is consistent with the relevance of these nuclear receptors in gallstone for- mation. In addition, there is emerging data that also suggests a role for estrogen receptor ESR1 in abnormal choles- terol metabolism leading to gallstone disease. A better comprehension of the role of nuclear receptor function in gall- stone formation may help doctors to design new and more effective therapeutic strategies for this highly prevalent dis- ease condition.

关 键 词：核受体 肝脏X受体 胆汁酸受体 雌激素受体 胆固醇结石 

分 类 号：R657.42[医药卫生—外科学]