CKIP-1与骨质疏松的最新研究进展  

Progress of research on the relationship between CKIP-1 and osteoporosis

作　　者：胡炯[1] 王博[2] 吴鹏[2] 史晓林[1] 

机构地区：[1]浙江中医药大学附属第二医院骨科,杭州310005 [2]浙江中医药大学,杭州310053

出　　处：《中国骨质疏松杂志》2016年第8期1053-1057,共5页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金项目(81373878);浙江省自然科学基金项目(LY12H29007;LY13H290009)

摘　　要：骨质疏松是严重威胁中老年人健康的骨科常见病。酪蛋白激酶2相互作用蛋白1(casein kinase 2 interaction protein 1,CKIP-1)是近年来发现的一种重要分子,它通过与其他分子的相互作用在许多细胞行为中都发挥着重要的作用。CKIP-1是参与调节骨形成的最重要的蛋白因子,与骨质疏松有密切联系,并已成为药物设计的新靶点。因此,对其的深入研究将为骨质疏松、病理机制阐明及骨疾病防治带来积极影响。本文就CKIP-1与骨质疏松症的关系进行综述。Osteoporosis is a common health problem worldwide that affects many older people. Casein kinase 2 interaction protein1（ casein kinase 2 interaction protein 1,CKIP-1） is an important molecule discovered in recent years. It plays an important role in many cell behaviors through its interaction with other molecules. CKIP-1 has been attributed a critical role in regulating bone remodeling. It has close relationship with osteoporosis,and is a target for developing newdrugs for the treatment of osteoporosis.Therefore,in depth research on CKIP-1 will contribute to the prevention of osteoporosis and other bone diseases as well as understanding the pathogenesis of these diseases. This article reviews the relationship between CKIP-1 and osteoporosis.

关 键 词：酪蛋白激酶2相互作用蛋白1 骨质疏松 泛素连接酶 

分 类 号：R589.5[医药卫生—内分泌]