川崎病患儿急性期低钾血症与炎性指标及冠脉损伤的关系  

RESEARCH ON RELATIONSHIP BETWEEN HYPOKALEMIA AND INFLAMMATORY INDICES,CORONARY ARTERY LESIONS IN CHILDREN WITH KAWASAKI DISEASE IN THE ACUTE PHASE

作　　者：杨欣[1] 鲁利群[1] 黄莉[1] 汪燕[1] 王旭[1] 邓国清[1] 

机构地区：[1]成都医学院第一附属医院儿科,四川省成都市610500

出　　处：《中国煤炭工业医学杂志》2016年第8期1164-1167,共4页Chinese Journal of Coal Industry Medicine

摘　　要：目的探讨川崎病患儿急性期出现的低钾血症与炎性指标及冠状动脉损伤的关系。方法选择2011年5月—2015年5月确诊为川崎病的急性期患儿95例。采集患儿静脉血样进行白细胞计数、超敏C反应蛋白及血清前白蛋白的检测,并通过超声心动图检查冠状动脉损害情况。根据血钾水平将95例川崎病急性期患儿分为低血钾组38例和正常血钾组57例。低血钾组根据血钾水平再细分为轻度、中度及重度低血钾3个亚组。比较低血钾组和正常血钾组炎性指标白细胞计数、C反应蛋白、血清前白蛋白以及冠状动脉损伤(CALs)的发生率,并进行低血钾各亚组与正常血钾组的比较。应用Pearson相关性分析低钾血症与炎性指标(白细胞计数、C反应蛋白、血清前白蛋白)的关系。结果低血钾组CALs发生率(42.11%)较正常血钾组(15.79%)明显增高,差异有统计学意义(P<0.01),低血钾组中度和重度亚组发生CALs率与正常血钾组比较,差异有统计学意义(P<0.05);低血钾组白细胞计数明显高于正常血钾组,差异有统计学意义(P<0.05),其中中度和重度亚组与正常血钾组比较差异有统计学意义(P<0.05);低血钾组C反应蛋白结果明显高于正常血钾组,差异有统计学意义(P<0.05),其中中度和重度亚组与正常血钾组比较差异有统计学意义(P<0.05);低血钾组血清前白蛋白水平低于正常血钾组,差异有统计学意义(P<0.05),其中中度和重度低钾血症组与正常血钾组比较差异有统计学意义(P<0.01)。低钾血症的水平与白细胞计数、C反应蛋白的水平呈负相关,与血清前白蛋白的水平呈正相关,其中中重度亚组与上述炎性指标相关性较好。结论川崎病患儿急性期常出现低钾血症,同时川崎病急性期出现的低钾血症可作为预测川崎病患儿CALs的发生及针对CALS的预防性治疗的参考指标。Objective To explore the relationship between hypokalemia and inflammatory indices, coronary artery lesions in children with Kawasaki Disease（KD） in the acute phase. Methods Ninety- five children with KD in the acute phase were enrolled. Venous blood samples were gathered and the levels of WBC, hs- CRP, Prealbumin （PA） in the serum were detected. The coronary artery was checked by cardiac ultrasonic examination. The ninety - five cases of children were divided into hypokalemia group and normal potassium group according to the level of potassium. The hypokalemia group was further divided into mild hypokalemia, moderate and severe hypokalemia subgroups. The inflammatory indices, WBC, CRP and PA in the serum and coronary artery lesions, were compared between hypokalemia group and normal potassium group. The comparison was also made between the sub- groups and the normal group. Pearson correlation Coefficient were used to analyze the correlation between hy- pokalemia and inflammatory makers（WBC, hs- CRP, PA）. Results The incidence of CALs in hypokalemia （42. 11%） was increased greatly compared with the normal potassium group（15.79）, and the difference was statisti- cally significant（P〈0.01）, same as between the moderate, severe hypokalemia subgroups and the normal group （P〈0.05）. The level of WBC, hs- CRP in the hypokalemia group was obviously higher than the normal group, and the difference was statistically significant（P〈0. 05）. The differences were also statistically significant be- tween the moderate, severe hypokalemia subgroups and the normal group（P〈0. 05） ; but the level of serum PA in the hypokalemia group was obviously lower than the normal group, and the difference was statistically significant （P〈0.05）. The differences were also statistically significant between the moderate, severe hypokalemia sub- groups and the normal group（P〈0. 01）. The blood potassium had positive correlation with WBC,hs- CRP, and had the negative correlation with serum PA. The

关 键 词：川崎病 急性期 低钾血症 炎性指标 冠状动脉 儿童 

分 类 号：R725.4[医药卫生—儿科]