弓形虫感染对中枢神经系统的损伤机制及其对宿主行为的影响  

Toxoplasma gondii infection induction of the damage of the central nervous system and its adverse effect on the behavior of host

作　　者：程正阳[1] 张贤[1] 苏蕊[1] 余莉[1] 

机构地区：[1]安徽医科大学病原生物学教研室、人兽共患病安徽省重点实验室、安徽病原生物学省级实验室,合肥230032

出　　处：《中国人兽共患病学报》2016年第8期751-754,共4页Chinese Journal of Zoonoses

摘　　要：弓形虫是引起人畜共患弓形虫病的病原体,它的感染范围广泛,感染途径多样,对人类健康和畜牧业发展危害极大。弓形虫感染与人类神经系统疾病关系密切,感染者常常会表现出反应迟钝,性格缺失等行为异常,严重时还会出现精神分裂,情绪失控,自主暴力等精神性问题。本文主要从弓形虫入侵中枢神经系统的机制,对中枢神经系统的影响和宿主行为学的变化3个方面进行综述。Toxoplasma gondii is an important zoonotic pathogen.It infects a wide range of hosts through varied routes and brings a great harm to human health and animal husbandry.T.gondii infection is closely associated with a variety of neurological disorders,and patients infected with T.gondii may exhibit behavioral abnormalities and mental problems such as schizophrenia,emotional dissonance and self-violence.Here the invasion mechanism,pathogenesis of the central nervous system and the changes of host behavior caused by T.gondii are reviewed.

关 键 词：弓形虫 中枢神经系统 宿主行为 

分 类 号：R338.2[医药卫生—人体生理学]