藻酸盐敷料和凡士林纱布对瘢痕皮肤供皮区创面愈合及相关分子表达的影响  

Effect of alginate dressing and petrolatum gauze on wound healing and related molecule expression in scar-skin donor site

作　　者：邬天刚[1] 冯登超[2] 

机构地区：[1]陕西省汉中市人民医院整形外科,陕西汉中723000 [2]延安大学附属医院烧伤整形手外科,陕西延安716000

出　　处：《海南医学院学报》2016年第16期1911-1913,1917,共4页Journal of Hainan Medical University

基　　金：延安市科学技术研究发展计划项目(2014KW-04)~~

摘　　要：目的：研究藻酸盐敷料和凡士林纱布对烧烫伤皮肤创面愈合及相关分子表达的影响。方法：选择2010年5月~2015年10月在我院接受植皮治疗的大面积烧伤患者64例,随机分为藻酸盐组和凡士林组,并采用不同的敷料进行供皮区换药。观察创面愈合情况并检测创面组织中转化生长因子-β1（TGF-β1）、碱性成纤维细胞生长因子（b FGF）、血管内皮生长因子（VEGF）、表皮细胞生长因子（EGF）的mRNA含量和蛋白含量。结果：藻酸盐组平均创面愈合时间显著短于凡士林组[（12.6±1.8）d vs（17.2±2.1）d],且换药后3、6、9 d时的创面愈合情况优于凡士林组（P〈0.05）;藻酸盐组创面组织中TGF-β1、bFGF、VEGF、EGF的mRNA含量和蛋白含量均显著高于凡士林组（P〈0.05）。结论：藻酸盐敷料能够促进瘢痕皮肤供皮区的创面愈合,有利于肉芽组织形成、血管新生以及上皮化过程。Objective： To study the effect of alginate dressing and petrolatum gauze on burned and scalded skin wound healing and relevant molecule expression. Methods： A total of 64 cases of patients with large-area burn who received skin grafting treatment in our hospital from May 2010 to October 2015 were selected for study and randomly divided into alginate group and petrolatum group who received different dressing for donor site dressing change. The wound healing was observed,and mRNA levels and protein levels of transforming growth factorβ1（ TGF-β1）,basic fibroblast growth factor（ b FGF）,vascular endothelial growth factor（ VEGF） and epidermal growth factor（ EGF） in wound tissue were determined. Results： The average wound healing time of alginate group was significantly shorter than that of petrolatum group [（ 12. 6 ± 1. 8 vs. 17. 2 ± 2. 1） d],and the wound healing conditions 3 d,6 d and 9 d after dressing change were significantly better than those of petrolatum group（ P〈0. 05）; mRNA levels and protein levels of TGF-β1,b FGF,VEGF and EGF in wound tissue of alginate group were significantly higher than those of petrolatum group（ P〈0. 05）. Conclusions： Alginate dressing can promote the wound healing in scar-skin donor site,and is conducive to the granulation tissue formation,angiogenesis and epithelization process.

关 键 词：藻酸盐 瘢痕 供皮区 肉芽组织 血管新生 

分 类 号：R622[医药卫生—整形外科]