消瘿方对40例桥本甲状腺炎患者血清TNF-α的影响及其临床疗效观察  

Influence of “Xiaoying Decoction” on the Level of Serum TNF-α in 40 Patients with Hashimoto Thyroditis and Its Clinical Efficacy

作　　者：周绍荣[1] 万华[1] 刘晓鸫[1] 张磊[1] 徐兆东[1] 赵亮[1] 李卓[1] 黄何尘 

机构地区：[1]上海中医药大学附属曙光医院中医外科,上海200021

出　　处：《上海中医药大学学报》2016年第4期31-34,共4页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：上海市卫生局青年科研项目(2013Y114);上海市进一步加快中医药事业发展三年行动计划项目(ZY3-JSFC-2-1038;ZY3-CCCX-1-1008);上海市青年医师培养资助项目

摘　　要：目的:观察消瘿方治疗桥本甲状腺炎(hashimoto thyroditis,HT)的临床疗效及其对患者血清肿瘤坏死因子-α(TNF-α)水平的影响。方法:将符合纳入标准的80例HT患者随机分为治疗组(40例)和对照组(40例),治疗组予消瘿方口服,对照组予优甲乐口服,疗程均为12周。评价两组患者的临床疗效,检测并比较两组患者的血清甲状腺球蛋白抗体(TGAb)、甲状腺过氧化物酶抗体(TPOAb)及TNF-α水平。结果:治疗后,治疗组和对照组的临床总有效率分别为82.50%和41.03%,组间临床疗效比较,差异有统计学意义(P<0.05)。治疗后,治疗组患者的TPOAb、TGAb水平较治疗前均显著降低(P<0.05);对照组患者的TPOAb、TGAb水平与治疗前比较,差异无统计学意义(P>0.05);两组患者的TPOAb、TGAb治疗前后差值比较,其差异有统计学意义(P<0.05)。治疗后,治疗组患者的血清TNF-α水平显著下降(P<0.05),且治疗组患者的TNF-α水平低于对照组(P<0.05)。结论:消瘿方治疗HT具有较好的临床疗效,且能明显降低患者的血清TNF-α水平,改善患者的自身免疫性损害。Objective： To observe the efficacy of ＂Xiaoying Decoction ＂in treating patients with hashimoto thyroditis（ HT） and its influence on the level of serum TNF-α. Methods： Eighty patients with HT were randomized into treatment group and control group,with 40 cases in each group. The patients in the treatment group were treated with ＂Xiaoying Decoction＂and the patients in the control group were treated with euthyrox,with a course of 12 weeks. The clinical efficacy of the two groups was evaluated and the levels of serum TGAb,TPOAb and TNF-α were detected and compared between the two groups.Results： After treatment,the total effective rates of the treatment group and the control group were 82. 50% and 41. 03%respectively,with statistical difference between the two groups（ P 〈 0. 05）. After treatment,the levels of serum TPOAb and TGAb in the treatment group significantly decreased（ P 〈 0. 05）; there were no statistical differences between before and after treatment on the levels of serum TPOAb and TGAb in the control group（ P 〉 0. 05）; there were statistical differences between the two groups on the levels of TPOAb and TGAb after treatment（ P 〈 0. 05）. After treatment,the level of serum TNF-α in the treatment group obviously decreased（ P 〈 0. 05）,and the level of TNF-α in the treatment group was lower than that in the control group（ P 〈 0. 05）. Conclusion： ＂Xiaoying Decoction＂shows good effect in the treatment of HT,and it can decrease the level of serum TNF-α and improve the immune damage for patients with HT.

关 键 词：桥本甲状腺炎 消瘿方 肿瘤坏死因子-Α 中医药疗法 

分 类 号：R285.6[医药卫生—中药学]