色素上皮衍生因子与氧化低密度脂蛋白的相关性研究  

Association between pigment epithelium-derived factor and oxidized-low density lipoprotein

作　　者：马守原[1] 朱平[1] 

机构地区：[1]中国人民解放军总医院南楼心血管内科,北京100853

出　　处：《中国心血管杂志》2016年第4期332-335,共4页Chinese Journal of Cardiovascular Medicine

基　　金：总后勤部卫生部保健专项科研课题(15BJZ37)~~

摘　　要：血管内皮功能障碍是动脉粥样硬化(atherosclerosis,AS)的启动环节,脂代谢紊乱是损伤内皮的重要因素。特别是氧化低密度脂蛋白(oxidized-low density lipoprotein,ox-LDL)沉积于内膜下,导致内皮下胶原暴露,单核细胞黏附,脂质进一步沉积,促进泡沫细胞形成。Ox-LDL在损伤内皮和启动AS过程中发挥重要作用。作为一种多功能糖蛋白,色素上皮衍生因子(pigment epitheliumderived factor,PEDF)的抗炎、抗氧化、抗血栓形成、抗血管新生及抗肿瘤等特性越来越受到关注。大量研究表明PEDF可能缓解内皮损伤,发挥抗AS作用。因此,深入探讨ox-LDL、PEDF在内皮功能障碍和AS发生发展过程中的相互作用,为进一步阐明AS的发病机制及其临床防治提供了新思路。Endothelial dysfunction is the initial step in atherosclerosis （ AS ） , and the disorder of lipid metabolism is an important factor for endothelial injury. In particular, oxidized-low density lipoprotein （ ox-LDL） is deposited in the intima,inducing the exposure of collagen,monocyte adhesion,and formation of foam cell. Ox-LDL plays a critical role in endothelial dysfunction and starts the process of AS. Pigment epithelium-derived factor （PEDF）,which is considered as a multifunctional glycoprotein,has been reported to have anti-inflammatory, anti-oxidative, anti-thrombogenic, anti-angiogenic and anti-tumor properties. Accumulating studies have shown that PEDF may alleviate endothelial injury and protect vessels against AS. This review is aimed to explore the interaction of ox-LDL and PEDF, which contributes to endothelial dysfunction and development of AS. This will be helpful for further understandings on pathogenesis,prevention and treatment of AS.

关 键 词：动脉粥样硬化 色素上皮衍生因子 氧化低密度脂蛋白 

分 类 号：R54[医药卫生—心血管疾病]