间接血凝试验在日本血吸虫病诊断中的价值研究  

Study on value of IHA in diagnosis of schistosomiasis japonica

作　　者：周杰[1] 官威[2] 危芙蓉[2] 阮瑶[2] 李胜明[1] 许静[2] 贾铁武[2] 周晓农[2] 

机构地区：[1]湖南省血吸虫病防治所,岳阳414000 [2]中国疾病预防控制中心寄生虫病预防控制所

出　　处：《中国血吸虫病防治杂志》2016年第4期375-380,共6页Chinese Journal of Schistosomiasis Control

基　　金：中英全球卫生支持项目(GHSP-OP101);湖南省科技厅项目(2012FJ4103)

摘　　要：目的评价间接血凝试验(IHA)在日本血吸虫病诊断中的应用价值。方法在Medline、中国知网、维普、万方数据库中收集1982-2014年有关IHA诊断日本血吸虫病的相关研究文献,采用Meta分析法进行评价。结果有21篇符合要求的文献纳入本研究。在实验室评估中,IHA法检测日本血吸虫病AUCSROC=0.990 6;但在现场应用中,AUCSROC=0.832 9;两者差异有统计学意义(Z=4.50,P<0.05)。结论 IHA在现场应用中的日本血吸虫病诊断价值低于在实验室评估中的诊断价值。在消除血吸虫病阶段,亟待开发现场应用价值高的诊断试剂。Objective To evaluate the value of indirect hemagglutination test（IHA）in schistosomiasis diagnosis. Methods The literature concerned schistosomiasis diagnosis with IHA in the databases of Medline,CNKI,VIP and Wanfang Data from 1982 to 2014 was collected and evaluated. Results Totally 21 articles which were satisfied with the research criteria were analyzed with the Metaanalysis method. The IHA method had high value in schistosomiasis diagnosis,the AUCSROC of IHA in laboratory evaluation was 0.990 6,while in filed evaluation was 0.832 9,and the difference between them was significant（Z=4.50,P〈0.05）. Conclusion The diagnosis value of IHA in field evaluation is less than that in laboratory. In the process of the elimination of schistosomiasis,developing a new and higher sensitive reagent in schistosomiasis diagnosis is needed.

关 键 词：日本血吸虫病 间接血凝试验 META分析 免疫诊断 

分 类 号：R532.21[医药卫生—内科学]