18-β-甘草次酸衍生物的合成与体外抗HBV活性研究  

Synthesis of 18-β-glycyrrhetinic acid derivatives and their anti-HBV activity in vitro

作　　者：孙航宇[1] 欧小洪 孙薛蛟 曾丽兰[1] 王欢[1] 董登祥[1] 

机构地区：[1]贵阳中医学院,贵州贵阳550025

出　　处：《贵州科学》2016年第4期1-4,共4页Guizhou Science

基　　金：黔科合院士站(2014)4013;省长基金(2070201-040-070857)

摘　　要：本文合成18-β-甘草次酸衍生物4个,采用MT法测定其18-β-甘草次酸衍生物的抗HBV活性。再进行样品抑制Hep G2.2.15细胞表达表面抗原(HBs Ag)的测试。通过测试样品GLY-1、GLY-5、GLY-9、GLY-10对HBs Ag的分泌表达有一定的抑制作用。Four 18-β-glycyrrhetinic acid derivatives were synthesized by carbohydrate chemistry modification, and the anti-HBV activities of these compounds were determined by MTT method. Their inhibition abilities on HepG2.2. 15 cells expressing HBsAg were tested. The resuks showed that GLY-1,GLY-5,GLY-9,GLY-10 have certain inhibitory effect on the secretory expression of HBsAg.

关 键 词：18-β-甘草次酸衍生物 抗HBV 生物活性 糖化学 

分 类 号：R979.9[医药卫生—药品]