2型糖尿病与结直肠癌相关性的研究进展  

Research on the Correlation Between Type 2 Diabetes Mellitus and Colorectal Cancer

作　　者：赵明[1] 习阳[1] 步世忠[1] 

机构地区：[1]宁波大学医学院糖尿病研究中心,中国浙江宁波315211

出　　处：《生命科学研究》2016年第4期365-370,376,共7页Life Science Research

基　　金：国家自然科学基金(81370165;31301068);宁波市科技创新团队资助项目(2014B82002);宁波市自然科学基金(2013A610209);宁波大学王宽诚基金资助项目;香港方润华基金资助项目

摘　　要：国内外的流行病学研究表明,2型糖尿病与结直肠癌的发病率逐年升高,且两者可能存在相关性。现主要从两者共有的危险因素,如性别差异、不良的生活方式、疾病家族史和胰岛素的治疗情况等,及疾病发生的分子机制如胰岛素样生长因子、高胰岛素血症、慢性炎症和氧化应激、长链非编码RNA及细胞自噬等角度阐述糖尿病与结直肠癌之间的关系。Domestic and international epidemiological researches have shown that the incidence rates of both type 2 diabetes mellitus and colorectal cancer are increasing gradually, and there may exist a correlation be- tween these two diseases. To clarify this, the studies concerning the relationship between diabetes and colorectal cancer were summarized here, including their common risk factors, such as gender differences, unhealthy lifestyle, the family history of diseases, insulin such as insulin-like growth factor, hyperinsulinernia, coding RNA and autophagy. treatment, etc., and the related molecular mechanisms chronic inflammation and oxidative stress, long nonoding RNA and autophagy.

关 键 词：2型糖尿病(T2DM) 结直肠癌(CRC) 危险因素 长链非编码RNA 细胞自噬 

分 类 号：R587.1[医药卫生—内分泌] R735.35[医药卫生—内科学]