HuN4-F112株高致病性猪繁殖与呼吸综合征弱毒疫苗免疫后病毒血症和抗体消长规律的试验报告  

The testing report of viremia and antibody levels changing rule after immunizing high pathogenicity PRRS attenuated vaccine(HuN4-F112 strain)

作　　者：曹明慧[1] 

机构地区：[1]中国兽医药品监察所,北京100081

出　　处：《现代畜牧兽医》2016年第8期37-41,共5页Modern Journal of Animal Husbandry and Veterinary Medicine

摘　　要：应用高致病性猪繁殖与呼吸综合征弱毒疫苗（HuN4-F112株）对28—30日龄的仔猪进行免疫，并定期采样检测，研究免疫后病毒血症持续时间和抗体消长规律，结果表明，病毒血症在免疫后第1周即可出现，最长可持续至免疫后第6周；疫苗免疫后，母源抗体明显下降，免疫后第3周平均阻断率最低为18％，此后开始上升，至免疫后第7周平均阻断率达到最高值85％，随后开始缓慢下降，至免疫后第16周时为54％。研究表明，HuN4-F112株高致病性猪繁殖与呼吸综合征疫苗免疫后病毒血症持续时间最长为6周，抗体水平在免疫后第7周时达到最高。Immunize the piglets which were 28 to 30-days-old with the HuN4-FI12 strain highly pathogenic PRRS（Porcine reproductive and respiratory syndrome） attenuated vaccine, observed the viremia duration and the changing rule of antibody levels after immunization through regular sam- pling detection. The results showed that, viremia can appear in the first week and be surviving for six weeks at most after immunization. After vaccine immunization, the maternal antibody de- clined significantly, the average blocking rate is maximum 85% in the seventh week, it began to decline slowly later, and the average blocking rate is 54% in the sixteenth week. This research shows that viremia can be surviving six weeks at most with HuN4-Fll2 strain highly pathogenic por- cine reproductive and respiratory syndrome attenuated vaccine, and antibody levels can reach the peak in the seventh week.

关 键 词：仔猪 高致病性猪繁殖与呼吸综合征弱毒疫苗(HuN4-F112株) 免疫 消长规律 

分 类 号：S852.659[农业科学—基础兽医学]