液相共沉淀法制备吉西他滨磁靶向纳米粒  

Liquid phase coprecipitation of gemcitabine magnetic-targeting nanoparticles

作　　者：刘卫[1] 薛克营[1] 柯明耀[1] 吴雪梅[1] 赵年贵[1] 林岩[1] 沈杰芳[1] 

机构地区：[1]厦门医学院附属厦门市第二医院,厦门市呼吸中心,厦门361021

出　　处：《国际药学研究杂志》2016年第4期727-730,739,共5页Journal of International Pharmaceutical Research

基　　金：福建省自然科学基金面上项目(2011D010)

摘　　要：目的采用液相共沉淀法制备吉西他滨磁靶向纳米粒,探索制备过程中的一些条件。方法观察不同搅拌速度、Fe^(3+)/Fe^(2+)比、p H、温度对四氧化三铁(Fe_3O_4)纳米粉的影响以及乳化水相/油相、超声时间、固化温度对磁靶向纳米粒的影响。结果制备Fe_3O_4纳米粉采用条件如下:800 r/min的搅拌速度、1.7∶1的Fe^(3+)/Fe^(2+)比、p H9、反应温度60℃,以及采用5∶40的水相/油相比、10 min的超声时间、100℃的固化温度。结论制备的Fe_3O_4纳米粉粒径小,纯度高,无团聚现象,制备的吉西他滨磁靶向纳米粒稳定性好。Objective To use the liquid phase coprecipitation method for preparing gemcitabine magnetic nanoparticles to the pouch,and explore the preparation process in a number of conditions. Methods The effect of different stirring speeds,Fe^（3＋）/Fe^（2＋） ratio,p H,temperature of Fe_3O_4 powder and emulsification condition,ultrasonic time,curing temperature on the preparation of targeted magnetic nanoparticles were observed. Results The preparation of Fe_3O_4 nanoparticles was as follows：800 r / min of stirring speed,1.7∶1 Fe^（3＋）/Fe^（2＋） ratio,p H=9,the reaction temperature of 60 ℃,and the 5∶40 water / oil compared,ultrasonic time of 10 min,100 ℃ curing temperature. Conclusion Fe_3O_4 powder with small particle size,high purity,and no agglomeration are prepared,the stability of the gemcitabine magnetic nanoparticles capsule is good.

关 键 词：液相共沉淀 吉西他滨 磁靶向纳米粒 四氧化三铁 乳化 高相液相 

分 类 号：R943[医药卫生—药剂学]