黔产金耳环不同提取部位镇痛抗炎作用研究  

Analgesic and anti-inflammatory activities of extracts from Asarum insigne D. in Guizhou province

作　　者：赵鸿宾[1] 王恒[1] 李雪营[1] 魏学军[1] 夏亚兰[1] 余跃生[1] 

机构地区：[1]黔南民族医学高等专科学校,贵州都匀558013

出　　处：《黔南民族医专学报》2016年第2期88-89,100,共3页Journal of Qiannan Medical College for Nationalities

基　　金：贵州省卫生厅黔南民族医学高等专科学校科技联合基金项目(gzwkj 2012-2-013号);贵州省优秀科技教育人才省长专项资金项目[黔省专合字(2010)156号]

摘　　要：目的:探讨黔产金耳环不同提取部位镇痛抗炎作用效果,并初步筛选活性部位。方法:采用乙酸扭体法实验研究不同部位提取物的镇痛作用;采用二甲苯诱发小鼠耳廓肿胀模型研究不同部位提取物抗炎作用。结果:金耳环不同部位提取物对乙酸诱发小鼠腹腔剧烈疼痛的镇痛均有一定的作用,其中正丁醇提取物对二甲苯致小鼠耳廓肿胀有显著的抑制作用,而其他部位提取物抑制作用不明显。结论:正丁醇提取液为抗炎的主要活性部位。Objective： To study the analgesia effects of different fractions of Asarum province, so as to identify the effective constituents of Asarum insigne. Methods： The insigne in Guizhou analgesic were ob- served with the response of writhes tests, and the effect of anti - inflammatory were studied using mice inflam- mation models induced by dimethylbenzene. Results： The extracts from different fractions of Asarum insigne reduced the acetic acid - induced pain in mice , among which the butanol extract showed more anti - inflam- matory effect. Conclusion： The results of the mouse＇s ear edema by dimethylbenzene indicated the butanol extract were better that other extracts from Asarum insigne.

关 键 词：金耳环 提取物 镇痛 抗炎 

分 类 号：R931.71[医药卫生—生药学]