血清胱抑素C(CysC)联合尿微量清蛋白(mALB)对妊娠早期肾损害的诊断价值  

Serum Cystatin C(CysC) and Urinary Albumin(mALB) in Diagnosis of Early Renal Damage in Pregnancy

作　　者：梁兴澜 丘美蓉 陈勇平[1] 

机构地区：[1]福建省龙岩市第二医院肾内科,福建龙岩364000

出　　处：《中外医疗》2016年第20期30-32,共3页China & Foreign Medical Treatment

摘　　要：目的探讨采用血清胱抑素C联合尿微量清蛋白检测妊娠高血压早期肾损害的效果,为妊娠高血压合并肾损害治疗提供科学依据。方法随机选取68例2013年1月—2016年1月在该院就诊的妊娠高血压患者作为研究对象,同时随机选取68名同一时期在该院就诊的正常孕妇作为对照组,比较分析妊娠高血压患者和正常孕妇血清胱抑素C和尿微量清蛋白,独立检测及联合检测妊娠高血压疾病患者早期肾损害的敏感性和特异性。结果在研究组与对照组孕妇血清中胱抑素C含量对比(2.21±0.79)VS(0.69±0.12,尿中微量清蛋白含量对比(40.54±18.96)VS(20.17±15.41),差异有统计学意义(P<0.05);血清中胱抑素C和尿中微量清蛋白含量独立及联合检测比较,显示联合检测的特异性和敏感性分别为(97.1%、95.8%)均明显高于单独检测,差异具有统计学意义(P<0.05)。结论妊娠高血压患者采用血清胱抑素C联合尿微量清蛋白评估妊娠高血压早期肾损害效果显著,有利于在疾病的早期发现患者的肾损害,从而及早进行对症治疗,值得进一步推广和应用。[Abstrct] Objective To investigate the clinical actual effect analysis combined with urine albumin in patients with pregnan-cy induced hypertension disease by detection of serum cystatin C in early renal damage, to provide a scientific basis for fur-ther effective treatment for the disease. Methods 68 cases were randomly selected in January 2013 -2016 year in January in our hospital for treatment of pregnancy induced hypertension patients as the research object, and randomly selected 68 cases of normal pregnant women during the same period of acceptance of delivery in our hospital as control group, compara-tive analysis of hypertension in normal pregnant women and patients with pregnancy blood albumin and urine cystatin C clear, single detection and two simultaneous detection of early renal damage in patients with hypertensive disorders in preg-nancy sensitivity and specificity. Results In serum albumin content in cystatin C content and urine, study group of pregnant women were higher than the control group of pregnant women, the difference was statistically significant （P〈0.05）;serum al-bumin content and independent of serum cystatin C and urine in early renal damage of hypertension in patients with preg-nancy specificity and sensitivity comparison results showed that the combined detection sensitivity and specificity were sig-nificantly higher than that of single detection, significant difference, statistically significant difference （P〈0.05）. Conclusion Combined urinary albumin in pregnancy induced hypertension patients using serum cystatin C in early renal damage dis-ease, higher sensitivity and specificity for the discovery of renal damage in patients with the early stage of the disease, so treatment is worthy of further promotion and application.

关 键 词：胱抑素C 微量清蛋白 妊娠 肾损害 诊断价值 

分 类 号：R714.258[医药卫生—妇产科学]