降钙素原在20例输入性疟疾诊治中的应用  

Application of procalcitonin in treatment and diagnosis of imported malaria:a study in 20 cases

作　　者：黄富礼 郑海三[2] 彭颖 邹永胜 钟利 黄永茂 

机构地区：[1]西南医科大学附属医院感染科,四川泸州646000 [2]四川省泸州市疾病预防控制中心,646000

出　　处：《检验医学与临床》2016年第16期2264-2266,共3页Laboratory Medicine and Clinic

基　　金：泸州市科技局资助项目[2014-s-45(7/12)];西南医科大学附属医院博士基金(14047)

摘　　要：目的 评价血清降钙素原（PCT）在20例输入性疟疾诊治中的价值。方法 回顾性分析该院2013年1月至2015年12月3年间输入性疟疾患者PCT检测结果与疟原虫分型、临床表现及预后的关系。结果 本研究共有20例患者进行了PCT检测,其结果100%（20/20）有升高,范围在0.38~100.00ng/mL。间日疟PCT为（0.85±0.58）ng/mL,最高达正常值30倍;恶性疟PCT为（28.20±34.50）ng/mL,最高达2 000倍。白细胞总数升高者占20%（4/20）,降低者占25%（5/20）。中性粒细胞比例升高者占95%（19/20）,中性粒细胞（NEU）/淋巴细胞（LYM）〉4倍者占75%（15/20）,PLT降低者占80%（16/20）。结论 恶性疟患者PCT升高程度明显高于间日疟患者,PCT高低及NEU/LYM值的大小可能预示输入性疟疾患者疾病严重程度及预后。Objective To evaluate the value of serum procalcitonin （PCT） in the diagnosis and treatment of 20 cases with impor-ted malaria .Methods Retrospective analysis was performed to analyze the relationship between the PCT results and plasmodium typing ,clinical manifestation and prognosis of imported malaria patients in Luzhou during the 3 years from January of 2013 to De-cember of 2015 .Results A total of 20 patients were detected for PCT ,and the results showed that level of PCT had increased in all the cases [100% （20/20）] ,which was in the range of 0 .38 to 100 .00 ng/mL .The level of PCT in vivax malaria was （0 .85 ± 0 .58） ng/mL ,maximum was up to 30 times than the normal value ,and which in falciparum malaria was （28 .20 ± 34 .50）ng/mL ,maxi-mum was up to 2 000 times than the normal value .Patients with increased white blood cell counted 20% （4/20） ,and patients with decreased white blood cell counted 25% .And patients with increased neutrophil ratio was up to 95% （19/20） ,and patients with in-creased neutrophil （NEU）/lymphocyte （LYM ） higher than 4 times accounted for 75% ,which with decreased PLT counted 80%（16/20） .Conclusion The level of PCT in falciparum malaria has increased more obviously than that in vivax malaria ,and level of PCL and NEU /LYM value may indicate severity and prognosis of imported malaria disease .

关 键 词：降钙素原 输入性疟疾 应用 

分 类 号：R531.3[医药卫生—内科学]