微小RNA对心肌梗死中心肌细胞活性的影响及治疗前景  

Influence of microRNAs on cardiomyocyte viability in myocardial infarction and its therapeutic potential:research progress

作　　者：王宁[1,2] 刘启龙[1] 郑丽红[1] 杨阳[2] 文平[1] 

机构地区：[1]大连医科大学附属儿童医院心脏中心,大连116012 [2]第四军医大学生物医学工程系卫生装备教研室,西安710032

出　　处：《第二军医大学学报》2016年第8期996-1001,共6页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金(81102687);第四军医大学博士学位资助课题(2013D01)~~

摘　　要：微小RNA(micro RNAs,miRs)是在真核生物中发现的一类内源性的具有调控功能的非编码RNA。心肌梗死(myocardial infaction,MI)是导致心脏重构和慢性心力衰竭的常见心血管事件,诸多miRs被发现在MI的病理生理机制中发挥重要作用。miRs对心肌细胞的存活及增殖活性有多方面影响,这些特性在治疗MI等缺血性心脏病中有着重要的指导意义。本文首先引入MI及miRs的研究概况,随后详细介绍了在心肌细胞存活及增殖中承担一定角色的miRs,最后展望了miRs应用于MI治疗的前景并提出局限性。MicroRNAs （miRs）, initially discovered in eukaryotes, are endogenous small noncoding RNAs that regulate gene expression. Myocardial infarction is a common cardiovascular event resulting in cardiac remodeling and subsequent chronic heart failure. A number of miRs have been reported to regulate important pathophysiological processes of myocardial infarction. They have multiple effects on the survival and proliferation of cardiomyocytes, which is of great significance to myocardial infarction and other ischemic heart diseases. In this review we introduced the general knowledge of myocardial infarction and miRs, and described several miRs which are crucial for survival and proliferation of cardiomyocytes. We also discussed the therapeutic potential and limitations of miRs in future treatment of myocardial infarction.

关 键 词：微RNAS 心肌梗死 心力衰竭 心脏肌细胞 

分 类 号：R542.22[医药卫生—心血管疾病]