交感神经节在支配心脏中的作用研究进展  

The research progress on sympathetic ganglions innervating function in the heart

作　　者：程立君[1] 李广平[1] 

机构地区：[1]天津市心血管病离子与分子机能重点实验室,天津医科大学第二医院心脏科,天津心脏病学研究所,天津300211

出　　处：《生命的化学》2016年第4期482-486,共5页Chemistry of Life

基　　金：天津市自然科学基金项目(16JCQNJC12000)

摘　　要：交感神经可支配心脏,并在心脏传导、调节心率、心肌收缩和舒张等方面具有重要作用。目前对支配心脏的交感神经的研究多数集中在心肌组织中分布的交感神经,实际上支配心脏的远端交感神经节(颈部神经节和星状神经节)也发挥着重要作用。文中简要介绍了交感神经节对心脏的支配情况,总结了交感神经节阻滞在心脏疾病治疗中的作用,讨论了交感神经节支配心脏的作用机制方面的研究现况,提出了可以应用细胞电生理、免疫组化分析、分子生物学等技术,对支配心脏的远端交感神经节在心脏疾病、药物及物理因子作用下的机制进行研究。这将对深层次揭示心脏疾病的发病机制及相关治疗药物和物理方法的研制提供一定的理论及实验参考。The sympathetic nerves can innervate heart, which play an important role in the regulation of cardiac conduction, heart rate, systolic and diastolic etc. Most studies have focused on sympathetic nerve in the heart. However, the distant sympathetic ganglions innervating the heart （for example cervical ganglions and stellate ganglions） have an important function. This paper briefly has introduced the distribution of dis- tant sympathetic ganglia, summarized the effect of sympathetic ganglions blockade in the treatment of heart diseases, and discussed the mechanism of sympathetic ganglions innervated the heart. Further, this paper has proposed the mechanism of sympathetic ganglions by the technologies of electrophysiological, immunohis- tochemical analysis and molecular biology technology etc., which will reveal the underlying mechanisms of heart disease, and provided theoretical and experimental reference for the research and development of related drugs and physical therapy methods.

关 键 词：交感神经节 心脏 离子通道 受体 研究进展 

分 类 号：R54[医药卫生—心血管疾病]