血清淀粉样肽1-40水平与冠心病患者冠状动脉病变的相关性及其临床意义  

Correlation and significance of serum Amyloid beta 1-40 level in patients with coronary heart disease

作　　者：王德国[1] 王俊[1] 孙义润 张奇[1] 邢文[1] 陈月云[1] 王安才[1] 

机构地区：[1]皖南医学院附属弋矶山医院老年医学科,安徽芜湖241001

出　　处：《临床心血管病杂志》2016年第8期790-793,共4页Journal of Clinical Cardiology

基　　金：国家自然科学基金项目(No:81200142);安徽省自然科学基金项目(No:1208085QH156);弋矶山医院人才引进科研基金项目(No:YR201506)

摘　　要：目的:探讨冠心病患者血清淀粉样肽1-40(Aβ1-40)浓度变化及其与冠状动脉(冠脉)病变的关系。方法:选取我院经造影确诊的冠心病患者300例及同期造影为非冠心病患者86例,采集基本临床资料及生化指标,以酶联免疫吸附法(ELISA法)检测Aβ1-40的浓度。Gensini评分判断冠脉病变的严重程度,分析Aβ1-40浓度与冠心病及其严重程度的相关性。结果:与对照组比较,冠心病组血清肌酐[(76.2±18.9)μmol/L∶(69.4±14.3)μmol/L,P<0.001]和Aβ1-40[(63.9±20.14)ng/L∶(55.9±17.1)ng/L,P<0.001]显著增高而高密度脂蛋白[(0.96±0.26)mmol/L∶(1.06±0.33)mmol/L,P<0.003]显著降低。Gensini评分重度(>40)的冠心病患者肌酐、葡萄糖、总胆固醇、低密度脂蛋白及Aβ1-40显著高于轻度(<20)患者(P<0.05)。相关分析显示血清Aβ1-40浓度与年龄、高血压、尿素、肌酐、高密度脂蛋白及Gensini分级等呈显著相关(P<0.05),在校正性别、年龄、高血压、肌酐、尿素及高密度脂蛋白后,Aβ1-40浓度仍与冠心病Gensini分级显著正相关(r=0.113,P=0.027)。结论:冠心病患者血清Aβ1-40显著升高,升高的Aβ1-40与冠心病冠脉Gensini分级显著正相关,提示血清Aβ1-40测定有可能成为临床冠脉病变评估的有效指标。Objective：To evaluate the changes of serum amyloid beta 1-40（Aβ1-40）and the association with coronary arterial lesions in the patients with coronary heart disease（CHD）.Method：Three hundreds of patients with CHD and 86 corrtrol patients without CHD as control diagnosed by coronary artery angiography in our hospital were included in this study.After collected basic clinical data and biochemical parameters,enzyme-linked immunosorbent assay（ELISA）was detected the serum levels of Aβ1-40 in all patients.A Gensini＇s scores system was used to determine the severity of coronary artery disease.Result：Compared with the control group,serum creatinine（76.2 ± 18.9vs 69.4 ±14.3,P〈0.001）and Aβ1-40（63.9 ± 20.14 vs 55.9 ± 17.1,P〈0.001）were significantly increased while high-density lipoprotein（0.96±0.26 vs 1.06±0.33,P〈0.003）was significantly reduced in patients with CHD.Serum creatinine glucose,total cholesterol,LDL and Aβ1-40 were significantly higher in patients with high Gensini＇s score（40）than in mild Gensini＇s score（20）.Spearman analysis showed that serum Aβ1-40 concentration was significantly correlated with age,hypertension,urea,creatinine,high density lipoprotein and Gensini score（P〈0.05）.After adjusted for sex,age,hypertension,creatinine,urea and high density lipoprotein,serum Aβ1-40 was still significantly positive correlated with Gensini＇s score（r=0.113,P=0.027）.

关 键 词：血清淀粉样肽1-40 冠心病 GENSINI评分 

分 类 号：R541.4[医药卫生—心血管疾病]