金黄色葡萄球菌ESAT-6分泌系统研究进展  

Research advances in ESAT-6 secretion system in Staphylococcus aureus

作　　者：王亚楠[1] 李敏[1] 

机构地区：[1]上海交通大学医学院附属仁济医院检验科,上海200127

出　　处：《上海交通大学学报（医学版）》2016年第8期1210-1214,共5页Journal of Shanghai Jiao tong University:Medical Science

基　　金：国家自然科学基金(81322025;81371875);上海曙光人才计划(12SG03);上海市科学技术委员会基金(14140901000;15411960500);上海市教育委员会高峰高原学科建设计划(20152513)~~

摘　　要：金黄色葡萄球菌是临床重要的致病菌,引起的感染可以累及全身各脏器,严重威胁人类健康。ESAT-6分泌系统广泛存在于革兰阳性菌。在金黄色葡萄球菌中,经典的ESAT-6通路由esxA、esxB及其他9个分子组成的基因簇构成,该系统分泌的ESAT-6/WXG100家族蛋白对金黄色葡萄球菌的毒力和免疫防御功能起到重要作用。该文就金黄色葡萄球菌ESAT-6分泌系统的研究进展进行综述。Staphylococcus aureus is an important opportunistic pathogen that causes a variety of infections, which can involve all organs in the body and seriously threat people’s health. The ESAT-6 secretion system widely exists in gram-positive bacteria. Typical ESAT-6 pathway is composed of a gene cluster consisting of esxA, esxB, and nine other molecules in Staphylococcus aureus. ESAT-6/WXG100 protein family secreted by this system plays a critical role in virulence and protective immunity of Staphylococcus aureus. This article reviews research advances in ESAT-6 secretion system in Staphylococcus aureus.

关 键 词：金黄色葡萄球菌 ESAT-6分泌系统 毒力 

分 类 号：R446.5[医药卫生—诊断学]