新活素对术后肺动脉高压患者NT-proBNP及血流动力学的影响  

Influences of recombinant human bran natriuretic peptide on plasma N-terminal pro-brain natriuretic peptide levels and hemodynamics in patients with postoperative pulmonary hypertension

作　　者：荣晓松[1] 徐勇[1] 盛玲[1] 荆朝辉[1] 韦柳炎[1] 李明秋[1] 

机构地区：[1]江苏省无锡市人民医院心血管外科,江苏无锡214023

出　　处：《实用临床医药杂志》2016年第13期5-7,14,共4页Journal of Clinical Medicine in Practice

摘　　要：目的观察新活素-重组人脑利钠肽(rh BNP)对临床心血管外科手术后肺动脉高压患者的治疗作用及NT-pro BNP和血流动力学的变化情况。方法将行冠状动脉旁路移植术、二尖瓣置换术后仍出现肺动脉高压患者随机分为2组,治疗组45例术后进行常规治疗,对照组45例术后给予新活素治疗。比较时间点NT-pro BNP水平及血流动力学指标,了解心脏恢复状态,判断手术预后。结果与对照组相比,治疗组术后即刻NT-pro BNP显著低于术前(P<0.05),心率及肺动脉压更趋于稳定,左室舒张末直径(LVEDD)降低,射血分数(EF)增加(P<0.05)。结论新活素能有效降低患者术后血浆NT-pro BNP的水平,稳定心率,降低肺动脉压。Objective To explore the influence of recombinant human bran natriuretic peptide （rh-BNP） on plasma N-terminal pro-brain natriuretic peptide （NT-proBNP） levels and hemody-namics in patients with postoperative pulmonary hypertension. Methods A total of 90 patients with pulmonary hypertension after coronary artery bypass grafting or replacement of mitral valve were randomly divided into two groups, 45 cases in each group. Treatment group was treated with regular treatment, while control group was treated with recombinant human bran natriuretic peptide. Level of NT- proBNP and hemodynamics were observed in both groups. Results Compared with the control group, the NT-proBNP level at the end of surgery in treatment group was significantly lower than that before surgery （P 〈 0.05）. The heart rate and mPAP became stable, and LVEDD reduced significantly and EF increased significantly （P 〈0.05）. Conclusion The recombinant human bran natriuretic peptide can effectively reduce the levels of NT-proBNP, stabilize the heart rate and reduce the mPAP.

关 键 词：新活素 肺动脉高压 NT-PROBNP 血流动力学 

分 类 号：R473.6[医药卫生—护理学]