颅脑损伤后综合征神经内分泌激素水平变化及临床意义  

The neuroendocrine hormone changes and clinical significance in the syndrome of brain injury

作　　者：徐伟光[1] 赵展[1] 殷利明[1] 钟德泉[1] 王文涛[1] 

机构地区：[1]广东药学院附属第一医院神经外科,广州510080

出　　处：《中华内分泌外科杂志》2016年第4期317-319,共3页Chinese Journal of Endocrine Surgery

基　　金：广东省医学科研基金（A2013324）

摘　　要：目的探讨颅脑损伤后综合征神经内分泌激素水平异常的发生率及临床意义。方法将脑外伤后综合征67例作为研究组，取同期脑外伤患者无颅脑损伤后综合征的95例作为对照组，用放射免疫法测定周围静脉血中FT3、FT4、TSH、生长激素（GH）、促肾上腺皮质激素（ACTH）、皮质醇（Cor）、泌乳素（PRL）、睾酮（T）、雌二醇（E2）、卵泡刺激素（FSH）、黄体生成素（LH）及孕酮（P）的浓度，统计分析颅脑损伤后综合征患者神经内分泌激素异常的发生率，对激素异常的患者进行激素替代治疗，观察疗效。结果颅脑损伤后综合征患者神经内分泌激素异常总体发生率为38．8％，对照组发生率为10．5％，2者比较差异有统计学意义（P〈0．05），激素异常的患者经相应的激素治疗后症状缓解率88．5％。结论颅脑损伤后综合征神经内分泌激素水平异常有较高的发生率，可作为颅脑损伤后综合征一项重要的检测指标，用于指导临床治疗。Objective To study the incidence and clinical significance of abnormal neuroendocrine hor- mone in patients with the syndrome of brain injury. Methods 67 cases with the syndrome of brain injury were included in the study group, and 95 cases without the post traumatic syndrome after brain injury were included in the control group. The level of FT3, FT4, TSH, growth hormone（GH）, andrenocortico hormone（ACTH）, cortisol （Cor）, prolactin （PRL）, testosterone （T）, estradiol （E2）, follicular stimulating hormone （FSH）, luteotropic hor- mone（LH）, and progesterone（P） in peripheral blood were measured by radioimmunoassay. The incidence of the abnormal neuroendocrine hormone after brain injury was statistically analyzed. Patients with abnormal hormone were given hormone replacement therapy and the curative effects were observed. Results The incidence of neu- roendocrine hormone abnormalities was 38.8% in patients with the syndrome of brain injury, while it was 10.5% in the control group. There was significant difference between the 2 groups（P〈0.05 ）. The symptom remission rate was 88.5% after hormone treatment. Conclusions There was a high incidence of abnormal neuroendocrine hor- mone secretion in patients with the syndrome of brain injury. The hormone level may be used as an important in- dex to guide clinical therapy.

关 键 词：脑损伤 综合征 神经内分泌 激素 

分 类 号：R651.15[医药卫生—外科学]