终末期肾病腹膜透析患者血清MMP-10水平与心室重塑的关系  

Serum MMP-10 level and its relationship with ventricular remodeling in patients with end-stage renal disease during peritoneal dialysis

作　　者：罗立成[1] 李瑜琳[2] 贾顺莲 

机构地区：[1]青海大学研究生院,西宁810000 [2]青海省人民医院 [3]西宁市第一人民医院

出　　处：《山东医药》2016年第30期9-12,共4页Shandong Medical Journal

基　　金：青海省科学技术厅基本科技计划项目(2014-ZJ-747)

摘　　要：目的探讨行腹膜透析的终末期肾病(ESRD)患者血清基质金属蛋白酶10(MMP-10)水平与心室重塑的关系。方法选择行腹膜透析治疗的ESRD患者43例,空腹抽取静脉血,检测血清MMP-10、Hb、总蛋白、白蛋白、尿素氮(BUN)、肌酐(Scr)、TC、TG、HDL及LDL水平。采用彩色多普勒超声心动仪,检测室间隔厚度等指标,计算左心室心肌质量指数(LVMI)。以室间隔厚度≥12 mm为室间隔肥厚标准,将患者分为室间隔肥厚、无室间隔肥厚两个水平;以LVMI男>125 g/m2、女>120 g/m2为左心室肥厚标准,将患者分为左心室肥厚、无左心室肥厚两个水平。比较有无室间隔肥厚及有无左心室肥厚患者的血液相关指标,分析血清MMP-10水平与腹膜透析患者发生室间隔肥厚及左心室肥厚的关系。结果行腹膜透析治疗的43例ESRD患者中,室间隔肥厚的发生率为46.51%,左心室肥厚的发生率为55.81%。无室间隔肥厚者血清MMP-10水平低于室间隔肥厚者,Hb、总蛋白、白蛋白水平均高于室间隔肥厚者(P均<0.05)。无左心室肥厚者血清MMP-10水平低于左心室肥厚者,Hb、总蛋白、白蛋白水平均高于左心室肥厚者(P均<0.05)。血清MMP-10水平增高为室间隔肥厚及左心室肥厚的独立危险因素(P均<0.05),血清白蛋白水平增高为室间隔肥厚及左心室肥厚的独立保护因素(P均<0.05)。结论血清MMP-10水平增高为行腹膜透析的ESRD患者发生室间隔肥厚及左心室肥厚的独立危险因素,白蛋白水平增高为其独立保护因素。Objective To explore the level of serum matrix metalloproteinases 10（ MMP-10） and its relationship with ventricular remodeling during peritoneal dialysis in patients with end-stage renal disease（ ESRD）. Methods We chose 43 ESRD patients undergoing peritoneal dialysis,and their vein blood was collected to measure the levels of Hb,total protein,albumin,blood urea nitrogen（ BUN）,serum creatinine（ Scr）,TC,TG,HDL,LDL and MMP-10. We used color Doppler ultrasound cardiograph to test the indexes such as interventricular septal thickness and calculated the left ventricular mass index（ LVMI）. With the interventricular spetal thickness ≥12 mm as the standard,we divided the patients into ventricular septal hypertrophy and non-ventricular septal hypertrophy groups. Meanwhile,we divided them into left ventricle hypertrophy and non-left ventricle hypertrophy groups with the standard that the LVMI of male 125 g / m^2 and the LVMI of female 120 g / m^2. We compared the indexes about biochemical and ventricular remodeling of patients with or without ventricular septal hypertrophy and left ventricle hypertrophy. We analyzed the relationships of MMP-10 with the occurrence of ventricular septal hypertrophy and left ventricle hypertrophy in peritoneal dialysis of patients. Results The occurrence rate of ventricular septal hypertrophy was 46. 51% in these ESRD patients in peritoneal dialysis,and the occurrence rate of left ventricle hypertrophy was 55. 81%. The level of MMP-10 was lower,but the levels of Hb,total protein and albumin were higher in patients with non-ventricular septal hypertrophy than those with ventricular septal hypertrophy（ all P〈 0. 05）.The level of MMP-10 was lower,but the levels of Hb,total protein and albumin were higher in patients with non-left ventricle hypertrophy than those with left ventricle hypertrophy（ all P〈 0. 05）. The increased level of MMP-10 was an independent risk factor for ventricular septal hypertrophy and left ventricle hypertrophy（ all P〈 0. 05）,and the

关 键 词：终末期肾病 腹膜透析 基质金属蛋白酶10 心室重塑 室间隔肥厚 左心室肥厚 

分 类 号：R692.5[医药卫生—泌尿科学] R459.5[医药卫生—外科学]