前列地尔联合美卡素治疗早期糖尿病肾病疗效观察  

The Effect of Combined Alprostadil with Micardis in Treating Early Diabetic Nephropathy

作　　者：李青山 黄灿茂[2] 

机构地区：[1]乌鲁木齐市平顶山医院内科,新疆乌鲁木齐,830001 [2]武警新疆总队医院肾病科,新疆乌鲁木齐,830091

出　　处：《中国血液流变学杂志》2015年第4期420-422,共3页Chinese Journal of Hemorheology

摘　　要：目的：探讨前列地尔（PGE1）联合美卡素在治疗早期糖尿病肾病（DN）中的临床疗效。方法收集住院66例早期DN患者，随机分为前列地尔组22例，美卡素组22例，联合组22例，进行4周临床观察治疗，分别比较三组血糖、尿素氮、血肌酐、尿肌酐、24 h尿蛋白定量、尿微量白蛋白水平的变化。结果治疗4周后，各组24 h尿蛋白定量及尿微量白蛋白等指标较治疗前均有明显好转（P﹤0.01）；而联合组的24 h尿蛋白定量及尿微量白蛋白较另两组改善更显著（P﹤0.01）。结论前列地尔联合美卡素治疗早期DN，能有效地发挥不同机理的协同作用，减少尿蛋白，更有助于延缓DN向中末期肾病发生和发展。Objective To discuss the clinical effect of combined Alprostadil with Micardis in treating early diabetic nephropathy.Methods 66 inpatients with early diabetic nephropathy were divided into three groups randomly： PGE1 treatment group （n=22）, Micardis treatment group （n=22） and combined treatment group （n=22）, to compare respectively the change of blood glucose, urea nitrogen, serum creatinine, urine creatinine, quantitative test of 24 h urinary protein and urinary microalbumin level of three groups after 4 weeks clinical observation and treatment.Results After 4 weeks treatment, quantitative test of 24 h urinary protein, urinary microalbumin and other medical indicators of all three groups were clearly improved than before （P﹤0.01）; quantitative test of 24 h urinary protein and urinary microalbumin of combined treatment group were much more improved than the other two groups （P﹤0.01）.Conclusion Apply of combined Alprostadil with Micardis in treating early diabetic nephropathy could work out a different mechanism of synergistic effect, reduce urinary protein, and help better slowing down the occurrence and the development of diabetic nephropathy into mid-stage and end-stage renal disease.

关 键 词：前列地尔 美卡素 糖尿病肾病 

分 类 号：R587.1[医药卫生—内分泌]