血浆(1,3)-β-D-葡聚糖检测对血液病患者侵袭性真菌病的诊断价值  

The detection of (1,3)-beta-D-glucosan in hematological patients with invasive fungal disease

作　　者：萧晨路[1] 韩立中[1] 倪语星[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院临床微生物科,上海200025

出　　处：《检验医学》2016年第8期675-678,共4页Laboratory Medicine

基　　金：卫生公益性行业科研专项(201002021)

摘　　要：目的：评价（1，3）-β-D-葡聚糖（BDG）检测（简称G试验）对恶性血液病患者侵袭性真菌病（IFD）的诊断价值。方法回顾性分析399例血液系统肿瘤患者每周2～3次的血浆G试验数据，以《血液病/恶性肿瘤患者侵袭性真菌感染的诊断标准与治疗原则（修订版）》中的标准作为判断标准，利用SPSS 11.5统计软件分析G试验对IFD的诊断价值。结果 G试验诊断IFD的敏感性为78.5%，特异性为79.8%，阳性预测值为75.0%，阴性预测值为82.7%。结论血浆BDG水平与IFD感染有直接联系，每周检测2～3次，结合影像学判断方法能帮助诊断和排除IFD，提高IFD临床诊治效果。Objective To evaluate the detection of （1,3）-beta-D-glucosan（BDG）（G test） in hematological patients with invasive fungal disease （IFD）. Methods A retrospective study was performed for 399 hematological malignancy patients,plasma G tests were performed for 2-3 times a week. The Principle and Diagnostic Criteria of the Disease of Hematopoietic System/Tumor in Patients with Invasive Fungal Infection（Revised Edition） was used as criteria. The diagnostic significance was evaluated by SPSS 11.5 software. Results The sensitivity of G test was 78.5% for the diagnosis of IFD,the specificity was 79.8%,the positive predictive value was 75.0%, and the negative predictive value was 82.7%. Conclusions Plasma BDG is correlated with IFD. Plasma G test should be taken 2-3 times per week. Combined with medical imaging,G test could improve the diagnosis of IFD and treatment efficiency and reduce the medical burden of patients.

关 键 词：(1  3)-β-D-葡聚糖 侵袭性真菌病 血液系统肿瘤 

分 类 号：R446.5[医药卫生—诊断学]