动物脂肪沉积程序化及精氨酸的调控作用  

Programming of Fat Tissue Deposition and Modulation of Arginine

作　　者：吕佳琪[1] 吴秋珏[2] 寇涛 王恬[1] 

机构地区：[1]南京农业大学动物科技学院,江苏南京210095 [2]河南科技大学动物科技学院,河南洛阳471003 [3]福建省畜牧总站,福建福州350003

出　　处：《动物医学进展》2016年第9期112-118,共7页Progress In Veterinary Medicine

基　　金：国家重点基础研究发展计划(973)(2012CB124703)

摘　　要：脂肪的过度沉积常伴随着胰岛素抵抗、Ⅱ型糖尿病等代谢病症,既危害人类健康,带来经济负担,也会在农业生产中影响畜牧产品的质量。脂肪的沉积,始于胚胎期脂肪组织的发育,是一系列程序化作用的结果。脂肪沉积受多方因素影响,营养干预可以通过胚胎环境中的糖皮质激素浓度、线粒体功能、表观遗传、食欲中枢发育等方面影响胚胎脂肪沉积程序化。论文阐述了动物出生前后营养状况对脂肪沉积程序化的作用,对脂肪沉积的机制进行了初步探讨,并介绍了精氨酸营养在脂肪沉积中的应用。饮食中添加精氨酸为治疗脂肪过度沉积,提高畜牧生产水平,改善人类生活质量,开拓了新的思路。The excessive deposition of fat is often associated with insulin resistance and type Ⅱ diabetes, which jeopardizes human health,costs additional expenditures, and affects the quality of livestock products. The deposition of fat originates from fetal development,which is the result of a series of programming. Fat deposition is under the influence of various factors,in which,the nutrition can modulate the fetal glucocor- ticoid level, the mitochondrial function, the epigenetics, the development of appetite, and program the fat deposition. This article dealt with the effects of perinatal nutritional status on the programming of fat deposition, provided us preliminary study on the fat deposition, and introduced the application of arginine on the fat deposition. Arginine supplement provided a new way for curing the excessive fat deposition,improving the livestock production and improving the quality of human life.

关 键 词：脂肪沉积 程序化 机制 精氨酸 

分 类 号：S852.33[农业科学—基础兽医学]