8-取代苯并呋喃[3,2-d]嘧啶类化合物的合成及其体外抗白血病细胞活性研究  

Synthesis of 8-substituent Benzofuran [3,2-d] Pyrimidine Derivatives and Evaluation of their Anti-leukemia Cells Activity

作　　者：杨毓溥 张前军[1] 许志玲[2] 卢永仲[3] 王兴东[2] 

机构地区：[1]贵州大学化学与化工学院,贵州贵阳550025 [2]贵州大学精细化工研究开发中心,贵州贵阳550025 [3]贵州理工学院药学院,贵州贵阳550007

出　　处：《贵州大学学报（自然科学版）》2016年第2期31-34,56,共5页Journal of Guizhou University:Natural Sciences

基　　金：贵州省自然科学基金黔科合字[2011]2067号

摘　　要：设计合成14个8-硝基或8-氨基苯并呋喃[3,2-d]嘧啶类目标化合物(2a-g,3a-g),其结构经EI-MS、1H NMR和IR光谱确证。采用MTT法评价目标化合物对人白血病细胞K562体外增殖抑制活性,结果显示所合成化合物对K562细胞均具有一定的抑制作用,且8-氨基苯并呋喃[3,2-d]嘧啶类化合物的抗增殖活性均高于8-硝基苯并呋喃[3,2-d]嘧啶类化合物。Fourteen 8-nitro or 8-amino benzofuran[ 3,2-d] pyrimidinederivatives were designed and synthesized through a series of reactions. The structures of target compounds were confirmed by EI-MS, 1H NMR andIR, The in vitro anti-proliferative activity against K562ceUs was evaluated by MTF assay.The results show all of the compounds display a content of inhibition effect against K562 cells. The inhibitionof8-amino benzofuran [ 3,2-d ] pyrimidine derivatives was greater than the 8-nitrobenzofuran [ 3,2-d] pyrimidine derivatives.

关 键 词：苯并呋喃[3 2-d]嘧啶衍生物 合成 抗白血病细胞 

分 类 号：O626[理学—有机化学]