血液中肺炎克雷伯菌碳青霉烯类耐药危险因素的调查  

The risk factors of carbapenem-resistant Klebsiella pneumonia blood infection

作　　者：邓琼[1] 徐群飞 周芸[1] 徐珍[1] 余奇[1] 饶思友[1] 唐素琴[1] 曹先伟[1] 

机构地区：[1]南昌大学第一附属医院医院感染管理科,江西南昌330006 [2]玉山县妇幼保健院检验科,江西南昌330006

出　　处：《中国微生态学杂志》2016年第7期816-818,共3页Chinese Journal of Microecology

基　　金：江西省科技厅重点项目(20152ACG70015)

摘　　要：目的探讨血液中分离的肺炎克雷伯菌耐碳青霉烯类抗菌药物的危险因素,为临床治疗提供理论依据。方法回顾性收集2009年6月至2012年12月期间血液中分离出肺炎克雷伯菌的住院患者的临床资料,采用病例对照研究,单因素分析和多因素Logistic回归分析血液感染肺炎克雷伯菌耐碳青霉烯类抗菌药物的危险因素。结果泌尿道插管、血型(A型)、使用氨基糖苷类及抗真菌类抗菌药物是血液感染肺炎克雷伯菌耐碳青霉烯类抗菌药物的独立危险因素。结论临床治疗过程中,需要特别注意的环节是:泌尿道插管;氨基糖苷类和抗真菌类抗菌药物的合理使用。Objective To investigate the risk factors of carbapenem-resistant Klebsiella pneumonia blood infection, and provide a theoretical basis for clinical treatment. Methods A restrospective analysis was performed to investigate the risk factors of carbapenem resistance of Klebsiella pneumoniae isolated from the blood of inpatients. The clinical data of patients with Klebsiella pneumonia blood infection from June 2009 to December 2012 were collected, and Univariate analysis and multiple logistic regression analysis were performed. Results Multivariate logistic regression analysis showed that catheterization, blood type （A-type）, use of aminoglycoside antibiotics and antifungal drugs were the independent risk factors of blood infection with Klebsiella pneumoniae resistant to carbapenem antibiotics. Conclusion We should pay special attention to urinary catheterization and rational use of aminoglycoside antibiotics and antifungal drugs.

关 键 词：肺炎克雷伯菌 碳青霉烯类耐药 危险因素 

分 类 号：R446.5[医药卫生—诊断学]