功能化石墨烯在第三代电化学生物传感器中的应用研究  

The applications of functionalized graphene in the third generation biosensor

作　　者：张玲[1,2] 张谦[3] 

机构地区：[1]沈阳师范大学化学化工学院,沈阳110034 [2]沈阳师范大学能源与环境催化研究所,沈阳110034 [3]辽宁大学化学院,沈阳110036

出　　处：《中国科学：化学》2016年第8期745-758,共14页SCIENTIA SINICA Chimica

基　　金：国家自然科学基金(编号:21203126);辽宁省高等学校优秀人才支持计划(编号:LJQ2013112);辽宁省高等学校杰出青年学者成长计划(编号:LJQ2014003)资助项目

摘　　要：石墨烯因具有大的比表面积、完整的?-?共轭结构及良好的生物相容性和优良的导电性能等特性,受到电化学研究者们的广泛关注.然而在应用过程中,本征态石墨烯存在水溶性差、与介质的相互作用较弱、易团聚等问题.通过使用非共价、共价、氮掺杂修饰的方法对石墨烯进行功能化,较好地改善了这一问题,扩展了石墨烯在电化学领域的应用.自2009年首次将功能化石墨烯应用于第三代电化学生物传感器的研究以来,近几年相关研究呈增多的态势.本文系统总结了自2009年以来,功能化石墨烯作为新型电极修饰材料在第三代电化学生物传感器研究中的相关工作,并阐述了其在该领域发展中遇到的问题.Graphene has attracted considerable attentions from electrochemical researchers due to its large specific surface area, integrated ？-？ conjugated structure and good biocompatibility and excellent electrical properties. However, intrinsic graphenes cannot be dispersed in most of solvents, weakly interact with the media and easily integrated, which greatly hampers their researches and potential utilities. In order to solve these problems, the methods of non-covalent, covalent modification and nitrogen-doped were applied to functionalize graphene. The synthesis of functionalized graphene extends the application of graphene in field of electrochemistry. Functionalized graphene was firstly applied in the third generation electrochemical biosensors since 2009 and the correlative reports increased in recent years. This review summarized the researches of functionalized graphene as novel modified electrode materials in the third-generation biosensors since 2009. Also, the related problems encountered in the development of the third-generation biosensor were also discussed.

关 键 词：石墨烯 功能化 氧化还原蛋白质 第三代电化学生物传感器 

分 类 号：O613.71[理学—无机化学] TP212[理学—化学]