基于肱动脉的中心动脉压力波无创检测仪  

Non-Invasive Detector of Central Aortic Pulse Wave Based on Brachial Pulse Wave

作　　者：玉荆泉 付强[2] 姚阳[2] 柳程奕 赵军超[2] 王璐[3] 郝丽玲[2] 徐礼胜[2] 

机构地区：[1]沈阳恒德医疗器械研发有限公司,辽宁沈阳110179 [2]东北大学中荷生物医学与信息工程学院,辽宁沈阳110167 [3]东北大学计算机科学与工程学院,辽宁沈阳110819

出　　处：《中国医疗设备》2016年第8期9-15,共7页China Medical Devices

基　　金：国家自然科学基金项目(61374015"基于弹性管非线性模型盲辨识的中心动脉波无创动态重建研究"和61202258"面向智能视频监控的多目标检测与跟踪技术研究");辽宁省自然科学基金项目(201102067);教育部博士点基金项目(20110042120037);中央高校基本科研业务费(N110219001;N130404016)

摘　　要：目的运用传递函数法通过外周肱动脉脉搏来估测中心动脉压力波,并联合心音、心电信号辅助估测中心动脉的血流动力学重要参数。方法中心动脉压力波对分析人体心血管系统功能至关重要,然而它却不能直接无创测量。本文首先针对每个个体建立了从肱动脉到中心动脉的个体化传递函数模型,然后将个体模型整合成为通用的传递函数模型。结果通过临床实验评估,发现运用传递函数法能很好的重建中心动脉压力波形。结论该方法提供了一种实现无创检测中心动脉参数的简单手段。Objective To adopt the transfer function method to estimate the central aortic pressure wave through peripheral brachial pulse wave, and to estimate the main parameters of the hemo-dynamics of the central artery in combination with the heart sound and ECG signals. Methods Central aortic pressure wave is essential to the analysis of the function of cardiovascular systems, but it cannot be measured noninvasively. In this paper, the Individualized Transfer Function（ITF） model of the vascular system from the brachial artery to the central artery is established for each individual. Then the individual models are integrated into a Generalized Transfer Function（GTF） model. Results By means of clinical laboratory evaluation and the comparison between estimated central aortic waveform and the invasively measured central artery waveforms, it is found that the use of the transfer function method can well reconstruct the central artery pressure waveform, and its parameters are estimated accurately. Conclusion This paper provides an efficient and feasible method to obtain the parameters of central aortic pulse wave noninvasively.

关 键 词：传递函数法 肱动脉 中心动脉压力波 无创检测仪 ARX模型 

分 类 号：TP274[自动化与计算机技术—检测技术与自动化装置] R54[自动化与计算机技术—控制科学与工程]